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The demographics of the ubiquitin system
The ubiquitin system is a major coordinator of cellular physiology through regulation of both
protein degradation and signalling pathways. A key building block of a systems-level …
protein degradation and signalling pathways. A key building block of a systems-level …
The family of ubiquitin‐conjugating enzymes (E2s): deciding between life and death of proteins
The family of ubiquitin‐conjugating (E2) enzymes is characterized by the presence of a
highly conserved ubiquitin‐conjugating (UBC) domain. These domains accommodate the …
highly conserved ubiquitin‐conjugating (UBC) domain. These domains accommodate the …
The p53 orchestra: Mdm2 and Mdmx set the tone
The activities of p53 cover diverse aspects of cell biology, including cell cycle control,
apoptosis, metabolism, fertility, differentiation and cellular reprogramming. Although loss of …
apoptosis, metabolism, fertility, differentiation and cellular reprogramming. Although loss of …
[HTML][HTML] MuRF1/TRIM63, master regulator of muscle mass
D Peris-Moreno, D Taillandier, C Polge - International journal of …, 2020 - mdpi.com
The E3 ubiquitin ligase MuRF1/TRIM63 was identified 20 years ago and suspected to play
important roles during skeletal muscle atrophy. Since then, numerous studies have been …
important roles during skeletal muscle atrophy. Since then, numerous studies have been …
Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne
A Bremm, SMV Freund, D Komander - Nature structural & molecular …, 2010 - nature.com
Ubiquitin is a versatile cellular signaling molecule that can form polymers of eight different
linkages, and individual linkage types have been associated with distinct cellular functions …
linkages, and individual linkage types have been associated with distinct cellular functions …
The evolving role of ubiquitin modification in endoplasmic reticulum-associated degradation
GM Preston, JL Brodsky - Biochemical Journal, 2017 - portlandpress.com
The endoplasmic reticulum (ER) serves as a warehouse for factors that augment and control
the biogenesis of nascent proteins entering the secretory pathway. In turn, this compartment …
the biogenesis of nascent proteins entering the secretory pathway. In turn, this compartment …
An adaptive stress response that confers cellular resilience to decreased ubiquitination
LC Hunt, V Pagala, A Stephan, B ** of endoplasmic reticulum ubiquitin ligases identifies modulators of innate immune signalling
Ubiquitin ligases (E3s) embedded in the endoplasmic reticulum (ER) membrane regulate
essential cellular activities including protein quality control, calcium flux, and sterol …
essential cellular activities including protein quality control, calcium flux, and sterol …