Ganoderma lucidum has a long history of medicinal uses in the Far East countries of more
than 2000 years due to its healing properties. Recently, G. lucidum has come under …

Some medically important viruses―including retroviruses, flaviviruses, coronaviruses, and
herpesviruses―code for a protease, which is indispensable for viral maturation and …

Viral infections kill millions of people and new antivirals are needed. Nontoxic drugs that
irreversibly inhibit viruses (virucidal) are postulated to be ideal. Unfortunately, all virucidal …

Dengue virus (DENV) infection causes serious health problems in humans for which no drug
is currently available. Recently, DENV NS2B-NS3 protease has been proposed as a primary …

Flaviviruses are known to cause a variety of diseases in humans in different parts of the
world. There are very limited numbers of antivirals to combat flavivirus infection, and …

Dengue fever is a dangerous infectious endemic disease that affects over 100 nations
worldwide, from Africa to the Western Pacific, and is caused by the dengue virus, which is …

Proteases are key enzymes in viral replication, and interfering with these targets is the basis
for therapeutic interventions. We previously introduced a hypothesis about conformational …

Viral proteases are indispensable for successful virion maturation, thus making them a
prominent drug target. Their enzyme activity is tightly spatiotemporally regulated by …

Mounting evidence indicates that Zika virus (ZIKV) is closely related to neurological
disorders such as microcephaly and Guillain-Barré syndrome. There are currently no …

Zika and Dengue viruses have attracted substantial attention from researchers in light of
recent outbreaks of Dengue fever and increases in cases of congenital microcephaly in …