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Immune cell regulation of glia during CNS injury and disease
Glial cells are abundant in the CNS and are essential for brain development and
homeostasis. These cells also regulate tissue recovery after injury and their dysfunction is a …
homeostasis. These cells also regulate tissue recovery after injury and their dysfunction is a …
Gene therapy for neurological disorders: progress and prospects
Adeno-associated viral (AAV) vectors are a rapidly emerging gene therapy platform for the
treatment of neurological diseases. In preclinical studies, transgenes encoding therapeutic …
treatment of neurological diseases. In preclinical studies, transgenes encoding therapeutic …
Protective functions of reactive astrocytes following central nervous system insult
M Linnerbauer, V Rothhammer - Frontiers in immunology, 2020 - frontiersin.org
Astrocytes play important roles in numerous central nervous system disorders including
autoimmune inflammatory, hypoxic, and degenerative diseases such as Multiple Sclerosis …
autoimmune inflammatory, hypoxic, and degenerative diseases such as Multiple Sclerosis …
Adeno-associated virus technologies and methods for targeted neuronal manipulation
Cell-type-specific expression of molecular tools and sensors is critical to construct circuit
diagrams and to investigate the activity and function of neurons within the nervous system …
diagrams and to investigate the activity and function of neurons within the nervous system …
Neurotransmitter-triggered transfer of exosomes mediates oligodendrocyte–neuron communication
Reciprocal interactions between neurons and oligodendrocytes are not only crucial for
myelination, but also for long-term survival of axons. Degeneration of axons occurs in …
myelination, but also for long-term survival of axons. Degeneration of axons occurs in …
Adeno-associated virus-based gene therapy for CNS diseases
Gene therapy is at the cusp of a revolution for treating a large spectrum of CNS disorders by
providing a durable therapeutic protein via a single administration. Adeno-associated virus …
providing a durable therapeutic protein via a single administration. Adeno-associated virus …
Gene therapy tools for brain diseases
Neurological disorders affecting the central nervous system (CNS) are still incompletely
understood. Many of these disorders lack a cure and are seeking more specific and effective …
understood. Many of these disorders lack a cure and are seeking more specific and effective …
Progresses towards safe and efficient gene therapy vectors
The emergence of genetic engineering at the beginning of the 1970′ s opened the era of
biomedical technologies, which aims to improve human health using genetic manipulation …
biomedical technologies, which aims to improve human health using genetic manipulation …
CNS myelination requires VAMP2/3-mediated membrane expansion in oligodendrocytes
Myelin is required for rapid nerve signaling and is emerging as a key driver of CNS plasticity
and disease. How myelin is built and remodeled remains a fundamental question of …
and disease. How myelin is built and remodeled remains a fundamental question of …
Site-specific phosphorylation of tau inhibits amyloid-β toxicity in Alzheimer's mice
Amyloid-β (Aβ) toxicity in Alzheimer's disease (AD) is considered to be mediated by
phosphorylated tau protein. In contrast, we found that, at least in early disease, site-specific …
phosphorylated tau protein. In contrast, we found that, at least in early disease, site-specific …