Heat shock protein 70 kDa: molecular biology, biochemistry, and physiology

JG Kiang, GC Tsokos - Pharmacology & therapeutics, 1998 - Elsevier
Heat shock proteins (HSPs) are detected in all cells, prokaryotic and eukaryotic. In vivo and
in vitro studies have shown that various stressors transiently increase production of HSPs as …

Role of heat shock proteins in protection from and pathogenesis of infectious diseases

U Zügel, SHE Kaufmann - Clinical Microbiology Reviews, 1999 - journals.asm.org
Increased synthesis of heat shock proteins (hsp) occurs in prokaryotic and eukaryotic cells
when they are exposed to stress. By increasing their hsp content, cells protect themselves …

Heat shock proteins as regulators of the immune response

AG Pockley - The lancet, 2003 - thelancet.com
Until recently, heat shock proteins (also known as heat stress proteins) have mostly been
regarded as intracellular molecules that mediate a range of essential housekee** and …

Heat-shock proteins induce T-cell regulation of chronic inflammation

W Van Eden, R Van der Zee, B Prakken - Nature Reviews Immunology, 2005 - nature.com
Immune responses to certain heat-shock proteins (HSPs) develop in almost all inflammatory
diseases; however, the significance of such responses is only now becoming clear. In …

Heat shock proteins and the immune response

SHE Kaufmann - Immunology today, 1990 - cell.com
Heat shock proteins (HSPs) or stress proteins are produced by prokaryotic and eukaryotic
cells in response to a variety of insults. After this original definition, it has become incre …

Identification of a site in glutamate receptor subunits that controls calcium permeability

RI Hume, R Dingledine, SF Heinemann - Science, 1991 - science.org
The neurotransmitter glutamate mediates excitatory synaptic transmission throughout the
brain. A family of genes encoding subunits of the non-N-methyl-D-aspartate (non-NMDA) …

IL-1-independent role of IL-17 in synovial inflammation and joint destruction during collagen-induced arthritis

E Lubberts, LAB Joosten, B Oppers… - The Journal of …, 2001 - journals.aai.org
T cell IL-17 displays proinflammatory properties and is expressed in the synovium of patients
with rheumatoid arthritis. Its contribution to the arthritic process has not been identified. Here …

Association between the 65-kilodalton heat shock protein, Streptococcus sanguis, and the corresponding antibodies in Behcet's syndrome

T Lehner, E Lavery, R Smith, R Van Der Zee… - Infection and …, 1991 - journals.asm.org
The etiology of Behcet's syndrome (BS) is unknown, but a number of streptococcal species
have been implicated. A hypothesis was postulated that a shared antigen, such as a stress …

Give us this day our daily germs

GAW Rook, JL Stanford - Immunology today, 1998 - cell.com
Modern vaccinations, fear of germs and obsession with hygiene are depriving the immune
system of the information input upon which it is dependent. This fails to maintain the correct …

Heat shock proteins, inflammation, and cardiovascular disease

AG Pockley - Circulation, 2002 - ahajournals.org
molecules would adversely influence protein homeostasis and a variety of intracellular
functions. One mechanism by which HSF1 activity is negatively regulated is by hsp70 …