Chronic kidney disease (CKD) affects over 850 million people globally, and there is an
urgent need to prevent its development and progression. During the last decade, new …

The pathogenetic mechanisms underlying the onset and the post-transplant recurrence of
primary focal segmental glomerulosclerosis (FSGS) are complex and remain yet to be fully …

Primary cultures of proximal tubule cells are widely used to model the behavior of kidney
epithelial cells in vitro. However, de-differentiation of primary cells upon culture has been …

Glomerular diseases are classified using a descriptive taxonomy that is not reflective of the
heterogeneous underlying molecular drivers. This limits not only diagnostic and therapeutic …

Kidney organoids are a promising model to study kidney disease, but their use is
constrained by limited knowledge of their functional protein expression profile. Here, we …

Despite clinical use of immunosuppressive agents, the immunopathogenesis of minimal
change disease (MCD) and focal segmental glomerulosclerosis (FSGS) remains unclear …

Focal segmental glomerulosclerosis (FSGS) is the morphologic manifestation of a spectrum
of kidney diseases that primarily impact podocytes, cells that create the filtration barrier of …

Background: The first spatially resolved transcriptomics platforms, GeoMx (Nanostring) and
Visium (10x Genomics) were launched in 2019 and were recognized as the method of the …

Elevated interferon (IFN) signaling is associated with kidney diseases including COVID-19,
HIV, and apolipoprotein-L1 (APOL1) nephropathy, but whether IFNs directly contribute to …

Introduction Dysregulation of sphingolipid and cholesterol metabolism contributes to the
pathogenesis of glomerular diseases (GDs). Apolipoprotein M (ApoM) promotes cholesterol …