Antibiotic resistance is one of the major challenges facing modern medicine worldwide. The
past few decades have witnessed rapid progress in our understanding of the multiple factors …

BACKGROUND Antibiotics are among the most important tools in medicine, but their efficacy
is threatened by the evolution of resistance. Since the earliest days of antibiotics, resistance …

Antimicrobial peptides are promising alternative antimicrobial agents. However, little is
known about whether resistance to small-molecule antibiotics leads to cross-resistance …

Persisters are transiently antibiotic-tolerant cells that complicate the treatment of bacterial
infections. Both theory and experiments have suggested that persisters facilitate genetic …

Currently, the effects of high antibiotic concentrations on the performance of microbiota and
antibiotic resistance genes (ARGs) in activated sludge (AS) process are not well …

Predicting the future is difficult, especially for evolutionary processes that are influenced by
numerous unknown factors. Still, this is what is required of drug developers when they …

Antimicrobial peptides (AMPs) are promising antimicrobials, however, the potential of
bacterial resistance is a major concern. Here we systematically study the evolution of …

Highlights•Combinations of antibiotics lead to synergistic and antagonistic drug
interactions.•The underlying mechanisms of drug interactions can be elucidated using novel …

The ability to predict the evolutionary trajectories of antibiotic resistance would be of great
value in tailoring dosing regimens of antibiotics so as to maximize the duration of their …

In experimental evolution, laboratory-controlled conditions select for the adaptation of
species, which can be monitored in real time. Despite the current popularity of such …