The medial frontal cortex and adjacent orbitofrontal cortex have been the focus of
investigations of decision-making, behavioral flexibility, and social behavior. We review …

Recent breakthroughs in artificial intelligence (AI) have enabled machines to plan in tasks
previously thought to be uniquely human. Meanwhile, the planning algorithms implemented …

People with damage to the orbitofrontal cortex (OFC) have specific problems making
decisions, whereas their other cognitive functions are spared. Neurophysiological studies …

The prefrontal cortex (PFC) enables a staggering variety of complex behaviors, such as
planning actions, solving problems, and adapting to new situations according to external …

Individual preferences for the flavor of different foods and fluids exert a strong influence on
behavior. Most current theories posit that preferences are integrated with other state …

Accurate navigation to a desired goal requires consecutive estimates of spatial relationships
between the current position and future destination throughout the journey. Although …

During decision-making, neurons in the orbitofrontal cortex (OFC) sequentially represent the
value of each option in turn, but it is unclear how these dynamics are translated into a choice …

Primates interact with the world by exploring visual objects; they seek opportunities to view
novel objects even when these have no extrinsic reward value. How the brain controls this …

Ventromedial prefrontal cortex (vmPFC) is vital for decision-making. Functional
neuroimaging links vmPFC to processing rewards and effort, while parallel work suggests …

Behavioral and economic theory dictate that we decide between options based on their
values. However, humans and animals eagerly seek information about uncertain future …