Ginger, a Possible Candidate for the Treatment of Dementias?

G Schepici, V Contestabile, A Valeri, E Mazzon - Molecules, 2021‏ - mdpi.com
As the human life expectancy increases, age-linked diseases have become more and more
frequent. The worldwide increment of dementia cases demands medical solutions, but the …

Dietary bitter ginger-derived zerumbone improved memory performance during aging through inhibition of the PERK/CHOP-dependent endoplasmic reticulum stress …

C Yang, M Zhao, Y Chen, J Song, D Wang, M Zou… - Food & Function, 2024‏ - pubs.rsc.org
PERK/CHOP pathway-mediated excessive endoplasmic reticulum (ER) stress is closely
linked to aging-related cognitive impairment (ARCD). Zerumbone (ZB), a naturally occurring …

Role of Zerumbone, a Phytochemical Sesquiterpenoid from Zingiber zerumbet Smith, in Maintaining Macrophage Polarization and Redox Homeostasis

WL Yeh, BR Huang, GW Chen, V Charoensaensuk… - Nutrients, 2022‏ - mdpi.com
Macrophages and microglia are highly versatile cells that can be polarized into M1 and M2
phenotypes in response to diverse environmental stimuli, thus exhibiting different biological …

Neuroprotective effect of Saroglitazar on scopolamine-induced Alzheimer's in rats: insights into the underlying mechanisms

G Sandeep Ganesh, P Konduri, AS Kolusu… - ACS Chemical …, 2023‏ - ACS Publications
Alzheimer's disease (AD) is one of the most prevalent and progressive neurodegenerative
disorders, hallmarked by increased amyloid-β deposition and enhanced oxidative load in …

Marrubium vulgare extract improves spatial working memory and oxidative stress damage in scopolamine-treated rats

MI Lazarova, ER Tsvetanova… - Journal of …, 2024‏ - content.iospress.com
Background: The cholinergic neuronal loss in the basal forebrain and increasing brain
oxidative stress are one of the main features of the brain suffering from Alzheimer's disease …

Effects of Sideritis scardica extract on scopolamine-induced learning and memory impairment in mice

MI Lazarova, LP Tancheva, KN Tasheva… - Journal of …, 2023‏ - content.iospress.com
Background: The neurodegenerative process in Alzheimer's disease, one of the most
common types of dementia worldwide, mostly affects the cholinergic neurotransmitter system …

Influence of rosiridin on streptozotocin-induced diabetes in rodents through endogenous antioxidants-inflammatory cytokines pathway and molecular docking study

I Kazmi, FA Al-Abbasi, SA AlGhamdi… - Journal of …, 2025‏ - Taylor & Francis
The research was undertaken to assess the antidiabetic activity of rosiridin in the
streptozotocin (STZ)-induced diabetic model. Type 2 diabetes mellitus was elicited …

[HTML][HTML] Resveratrol-Loaded Pluronic Micelles Ameliorate Scopolamine-Induced Cognitive Dysfunction Targeting Acetylcholinesterase Activity and Programmed Cell …

M Lazarova, M Stefanova, E Tsvetanova… - International Journal of …, 2024‏ - mdpi.com
Numerous experimental studies suggest the potential for resveratrol (RVT) to be useful in
the Alzheimer's disease treatment, but its low bioavailability limits its application. This study …