As a powerful paradigm, artificial intelligence (AI) is rapidly impacting every aspect of our
day-to-day life and scientific research through interdisciplinary transformations. Living …

Glomerular diseases are classified using a descriptive taxonomy that is not reflective of the
heterogeneous underlying molecular drivers. This limits not only diagnostic and therapeutic …

Research on cells and organ‐like tissues is critical in the fields of molecular biology, genetic
analysis, proteomics analysis, tissue engineering, and others. In recent years …

Patient-derived models (PDMs, particularly organoids and xenografts) are irreplaceable
tools for precision medicine, from target development to lead identification, then to …

Background Disruptions in gene expression associated with the glomerular basement
membrane (GBM) could precipitate glomerular dysfunction. Nevertheless, a comprehensive …

Inflammation plays a key role in both the onset and progression of various kidney diseases.
However, the specific molecular and cellular mechanisms by which inflammation drives …

In the intricately defined spatial microenvironment, a single fertilized egg remarkably
develops into a conserved and well-organized multicellular organism. This observation …

Previously, we found that Wnt and Notch signaling govern stem cells of clear cell kidney
cancer (ccRCC) in patients. To mimic stem cell responses in the normal kidney in vitro in a …

Kidney organoids are emerging as an increasingly applied model system to holds great
promise for transplantation to individuals with end-stage renal disease and as a useful tool …

Acute kidney injury (AKI) is a common clinical disorder linked to high rates of illness and
death. Ischemia is a leading cause of AKI, which can result in chronic kidney disease (CKD) …