Insights on molecular mechanisms of chondrocytes death in osteoarthritis

E Charlier, B Relic, C Deroyer, O Malaise… - International journal of …, 2016 - mdpi.com
Osteoarthritis (OA) is a joint pathology characterized by progressive cartilage degradation.
Medical care is mainly based on alleviating pain symptoms. Compelling studies report the …

Pathophysiological perspective of osteoarthritis

MHM Yunus, A Nordin, H Kamal - Medicina, 2020 - mdpi.com
Osteoarthritis (OA) is the most well-known degenerative disease among the geriatric and is
a main cause of significant disability in daily living. It has a multifactorial etiology and is …

Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis

T Hayami, M Pickarski, Y Zhuo, GA Wesolowski… - Bone, 2006 - Elsevier
Osteoarthritis (OA) is a chronic joint disease characterized by cartilage destruction,
subchondral bone sclerosis, and osteophyte formation. Subchondral bone stiffness has …

Biomarkers of joint damage in osteoarthritis: current status and future directions

R Kumavat, V Kumar, R Malhotra… - Mediators of …, 2021 - Wiley Online Library
Osteoarthritis (OA) is a disease of the whole joint organ, characterized by the loss of
cartilage, and structural changes in bone including the formation of osteophytes, causing …

Engineering of gradient osteochondral tissue: From nature to lab

S Ansari, S Khorshidi, A Karkhaneh - Acta biomaterialia, 2019 - Elsevier
The osteochondral tissue is an interface between two distinct tissues: articular cartilage and
bone. These two tissues are significantly diverse with regard to their chemical compositions …

A systematic review of the relationship between subchondral bone features, pain and structural pathology in peripheral joint osteoarthritis

AJ Barr, TM Campbell, D Hopkinson… - Arthritis research & …, 2015 - Springer
Introduction Bone is an integral part of the osteoarthritis (OA) process. We conducted a
systematic literature review in order to understand the relationship between non …

The effect of ageing and osteoarthritis on the mechanical properties of cartilage and bone in the human knee joint

AE Peters, R Akhtar, EJ Comerford, KT Bates - Scientific reports, 2018 - nature.com
Osteoarthritis is traditionally associated with cartilage degeneration although is now widely
accepted as a whole-joint disease affecting the entire osteochondral unit; however site …

Clinical implications of macrophage dysfunction in the development of osteoarthritis of the knee

J **e, Z Huang, X Yu, L Zhou, F Pei - Cytokine & growth factor reviews, 2019 - Elsevier
Osteoarthritis (OA) is the most common form of arthritic disease, leading to disability and
impaired quality of life and no curative treatments exist. Increasing evidence indicates that …

[HTML][HTML] Altered cartilage mechanics and histology in knee osteoarthritis: relation to clinical assessment (ICRS Grade)

RU Kleemann, D Krocker, A Cedraro, J Tuischer… - Osteoarthritis and …, 2005 - Elsevier
OBJECTIVE: Substantial changes in articular cartilage composition and mechanical
properties occur during the development of osteoarthritis (OA). While softening in the initial …

Subchondral bone microstructural damage by increased remodelling aggravates experimental osteoarthritis preceded by osteoporosis

M Bellido, L Lugo, JA Roman-Blas, S Castañeda… - Arthritis research & …, 2010 - Springer
Introduction Osteoporosis (OP) increases cartilage damage in a combined rabbit model of
OP and osteoarthritis (OA). Accordingly, we assessed whether microstructure impairment at …