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Regulation of FGF23 production and phosphate metabolism by bone–kidney interactions
The bone-derived hormone fibroblast growth factor 23 (FGF23) functions in concert with
parathyroid hormone (PTH) and the active vitamin D metabolite, 1, 25 (OH) 2 vitamin D (1 …
parathyroid hormone (PTH) and the active vitamin D metabolite, 1, 25 (OH) 2 vitamin D (1 …
FGF23 at the crossroads of phosphate, iron economy and erythropoiesis
Abstract Fibroblast growth factor 23 (FGF23) was initially characterized as an important
regulator of phosphate and calcium homeostasis. New research advances demonstrate that …
regulator of phosphate and calcium homeostasis. New research advances demonstrate that …
[HTML][HTML] Controversies in optimal anemia management: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Conference
In chronic kidney disease, anemia and disordered iron homeostasis are prevalent and
associated with significant adverse consequences. In 2012, Kidney Disease: Improving …
associated with significant adverse consequences. In 2012, Kidney Disease: Improving …
Tumor-induced osteomalacia
Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome caused by tumoral
production of fibroblast growth factor 23 (FGF23). The hallmark biochemical features include …
production of fibroblast growth factor 23 (FGF23). The hallmark biochemical features include …
Hormonal regulation of biomineralization
Biomineralization is the process by which organisms produce mineralized tissues. This
crucial process makes possible the rigidity and flexibility that the skeleton needs for …
crucial process makes possible the rigidity and flexibility that the skeleton needs for …
Bone-derived C-terminal FGF23 cleaved peptides increase iron availability in acute inflammation
Inflammation leads to functional iron deficiency by increasing the expression of the hepatic
iron regulatory peptide hepcidin. Inflammation also stimulates fibroblast growth factor 23 …
iron regulatory peptide hepcidin. Inflammation also stimulates fibroblast growth factor 23 …
[HTML][HTML] The role of fibroblast growth factor 23 in inflammation and anemia
In patients with chronic kidney disease (CKD), adverse outcomes such as systemic
inflammation and anemia are contributing pathologies which increase the risks for …
inflammation and anemia are contributing pathologies which increase the risks for …
New insights into the links between hypoxia and iron homeostasis
C Renassia, C Peyssonnaux - Current opinion in hematology, 2019 - journals.lww.com
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Hypoxia pathway proteins are master regulators of erythropoiesis
Erythropoiesis is a complex process driving the production of red blood cells. During
homeostasis, adult erythropoiesis takes place in the bone marrow and is tightly controlled by …
homeostasis, adult erythropoiesis takes place in the bone marrow and is tightly controlled by …
Osteocytic FGF23 and its kidney function
Osteocytes, which represent up to 95% of adult skeletal cells, are deeply embedded in bone.
These cells exhibit important interactive abilities with other bone cells such as osteoblasts …
These cells exhibit important interactive abilities with other bone cells such as osteoblasts …