Oxygen-derived free radicals, collectively termed reactive oxygen species (ROS), play
important roles in immunity, cell growth, and cell signaling. In excess, however, ROS are …

Context Tobacco smoking is a major worldwide cause of morbidity and mortality from
various diseases, including urologic diseases. Objective We reviewed, at global and …

Cigarette smoking is the leading cause of preventable morbidity and mortality. Genetic
variation contributes to initiation, regular smoking, nicotine dependence, and cessation. We …

Purpose Several lung cancer risk prediction models have been developed, but none to date
have assessed the predictive ability of lung function in a population-based cohort. We …

Smoking-associated DNA hypomethylation has been observed in blood cells and linked to
lung cancer risk. However, its cause and mechanistic relationship to lung cancer remain …

Cigarette smoking is a leading cause of preventable mortality worldwide. Nicotine
dependence, which reduces the likelihood of quitting smoking, is a heritable trait with firmly …

We conducted a 1000 Genomes–imputed genome-wide association study (GWAS) meta-
analysis for nicotine dependence, defined by the Fagerström Test for Nicotine Dependence …

Background: Light and/or intermittent smokers have been the fastest growing segment of
cigarette smokers in the United States over the past two decades. Defining their behavioral …

Background Incorporating tobacco treatment within lung cancer screening programs has the
potential to influence cessation in high-risk smokers. We aimed to better understand the …

Background Nicotine dependence is a key factor influencing the diversity of gut microbiota,
and targeting gut microbiota may become a new approach for the prevention and treatment …