Targeting and engineering long non-coding RNAs for cancer therapy

M Coan, S Haefliger, S Ounzain, R Johnson - Nature Reviews Genetics, 2024 - nature.com
RNA therapeutics (RNATx) aim to treat diseases, including cancer, by targeting or
employing RNA molecules for therapeutic purposes. Amongst the most promising targets …

MALAT1: A key regulator in lung cancer pathogenesis and therapeutic targeting

AA Bhat, O Afzal, M Afzal, G Gupta, R Thapa… - … -Research and Practice, 2024 - Elsevier
Lung cancer remains a formidable global health burden, necessitating a comprehensive
understanding of the underlying molecular mechanisms driving its progression. Recently …

[HTML][HTML] Long non-coding RNAs: from disease code to drug role

Y Chen, Z Li, X Chen, S Zhang - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Enormous studies have corroborated that long non-coding RNAs (lncRNAs) extensively
participate in crucial physiological processes such as metabolism and immunity, and are …

[HTML][HTML] MALAT1 Long Non-Coding RNA: Functional Implications

G Arun, D Aggarwal, DL Spector - Non-coding RNA, 2020 - mdpi.com
The mammalian genome is pervasively transcribed and the functional significance of many
long non-coding RNA (lncRNA) transcripts are gradually being elucidated. Metastasis …

lncRNAfunc: a knowledgebase of lncRNA function in human cancer

M Yang, H Lu, J Liu, S Wu, P Kim… - Nucleic acids research, 2022 - academic.oup.com
The long non-coding RNAs associating with other molecules can coordinate several
physiological processes and their dysfunction can impact diverse human diseases. To date …

Novel insights into the interplay between m6A modification and noncoding RNAs in cancer

YC Yi, XY Chen, J Zhang, JS Zhu - Molecular cancer, 2020 - Springer
Abstract N6-methyladenosine (m 6 A) is one of the most common RNA modifications in
eukaryotes, mainly in messenger RNA (mRNA). Increasing evidence shows that m 6 A …

Role of non-coding RNAs and RNA modifiers in cancer therapy resistance

X Zhang, K **e, H Zhou, Y Wu, C Li, Y Liu, Z Liu, Q Xu… - Molecular cancer, 2020 - Springer
As the standard treatments for cancer, chemotherapy and radiotherapy have been widely
applied to clinical practice worldwide. However, the resistance to cancer therapies is a major …

Noncoding RNAs in cancer therapy resistance and targeted drug development

WT Wang, C Han, YM Sun, TQ Chen… - Journal of hematology & …, 2019 - Springer
Noncoding RNAs (ncRNAs) represent a large segment of the human transcriptome and
have been shown to play important roles in cellular physiology and disease pathogenesis …

The genomic and transcriptional landscape of primary central nervous system lymphoma

J Radke, N Ishaque, R Koll, Z Gu, E Schumann… - Nature …, 2022 - nature.com
Primary lymphomas of the central nervous system (PCNSL) are mainly diffuse large B-cell
lymphomas (DLBCLs) confined to the central nervous system (CNS). Molecular drivers of …

LDA-VGHB: identifying potential lncRNA–disease associations with singular value decomposition, variational graph auto-encoder and heterogeneous Newton …

L Peng, L Huang, Q Su, G Tian, M Chen… - Briefings in …, 2024 - academic.oup.com
Long noncoding RNAs (lncRNAs) participate in various biological processes and have close
linkages with diseases. In vivo and in vitro experiments have validated many associations …