Apoptosis—the regulated destruction of a cell—is a complicated process. The decision to
die cannot be taken lightly, and the activity of many genes influence a cell's likelihood of …

Disturbances in the normal functions of the ER lead to an evolutionarily conserved cell
stress response, the unfolded protein response, which is aimed initially at compensating for …

Programmed cell death plays critical roles in a wide variety of physiological processes
during fetal development and in adult tissues. In most cases, physiological cell death occurs …

Anticancer treatment using cytotoxic drugs is considered to mediate cell death by activating
key elements of the apoptosis program and the cellular stress response. While proteolytic …

Human leukocyte antigen (HLA)-E binds epitopes derived from HLA-A, HLA-B, HLA-C and
HLA-G signal peptides (SPs) and serves as a ligand for CD94/NKG2A and CD94/NKG2C …

Protein-protein interactions are essential for the assembly, regulation, and localization of
functional protein complexes in the cell. SAM domains are among the most abundant protein …

Sterile alpha motif (SAM) domains are known to exhibit diverse protein–protein interaction
modes. They can form multiple self-association architectures and also bind to various non …

HLA-E is a non-classical class I MHC protein involved in innate and adaptive immune
recognition. While recent studies have shown HLA-E can present diverse peptides to NK …

Apoptosis is an important physiological process crucially involved in development and
homeostasis of multicellular organisms. Although the major signaling pathways have been …

Cardiolipin is a mitochondria-specific phospholipid known to be intimately involved with
apoptosis. However, the lack of appropriate cellular models to date restricted analysis of its …