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Juvenile idiopathic arthritis: from aetiopathogenesis to therapeutic approaches
Juvenile idiopathic arthritis (JIA) is the most common paediatric rheumatological disorder
and is classified by subtype according to International League of Associations for …
and is classified by subtype according to International League of Associations for …
[HTML][HTML] Silencing the cytokine storm: the use of intravenous anakinra in haemophagocytic lymphohistiocytosis or macrophage activation syndrome
The term cytokine storm syndromes describes conditions characterised by a life-threatening,
fulminant hypercytokinaemia with high mortality. Cytokine storm syndromes can be genetic …
fulminant hypercytokinaemia with high mortality. Cytokine storm syndromes can be genetic …
2021 American College of Rheumatology guideline for the treatment of juvenile idiopathic arthritis: therapeutic approaches for oligoarthritis, temporomandibular joint …
Objective To provide updated guidelines for pharmacologic management of juvenile
idiopathic arthritis (JIA), focusing on treatment of oligoarthritis, temporomandibular joint …
idiopathic arthritis (JIA), focusing on treatment of oligoarthritis, temporomandibular joint …
The 2022 EULAR/ACR points to consider at the early stages of diagnosis and management of suspected haemophagocytic lymphohistiocytosis/macrophage …
B Shakoory, A Geerlinks, M Wilejto, K Kernan… - Annals of the rheumatic …, 2023 - Elsevier
Objective Haemophagocytic lymphohistiocytosis (HLH) and macrophage activation
syndrome (MAS) are life-threatening systemic hyperinflammatory syndromes that can …
syndrome (MAS) are life-threatening systemic hyperinflammatory syndromes that can …
The IL-1 family of cytokines and receptors in rheumatic diseases
CA Dinarello - Nature Reviews Rheumatology, 2019 - nature.com
More than any other cytokine family, the 11 members of the IL-1 family are associated with
innate immune responses, which occur in acute inflammation and chronic inflammatory …
innate immune responses, which occur in acute inflammation and chronic inflammatory …
Hemophagocytic lymphohistiocytosis: an update on pathogenesis, diagnosis, and therapy
Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening state of immune
hyperactivation that arises in the setting of genetic mutations and infectious, inflammatory, or …
hyperactivation that arises in the setting of genetic mutations and infectious, inflammatory, or …
Efficacy and safety of emapalumab in macrophage activation syndrome
Objectives Macrophage activation syndrome (MAS) is a severe, life-threatening complication
of systemic juvenile idiopathic arthritis (sJIA) and adult-onset Still's disease (AOSD). The …
of systemic juvenile idiopathic arthritis (sJIA) and adult-onset Still's disease (AOSD). The …
Overview: systemic inflammatory response derived from lung injury caused by SARS-CoV-2 infection explains severe outcomes in COVID-19
Most SARS-CoV2 infections will not develop into severe COVID-19. However, in some
patients, lung infection leads to the activation of alveolar macrophages and lung epithelial …
patients, lung infection leads to the activation of alveolar macrophages and lung epithelial …
Interleukin-1 receptor blockade is associated with reduced mortality in sepsis patients with features of macrophage activation syndrome: reanalysis of a prior phase III …
B Shakoory, JA Carcillo, WW Chatham… - Critical care …, 2016 - journals.lww.com
Objective: To determine the efficacy of anakinra (recombinant interleukin-1 receptor
antagonist) in improving 28-day survival in sepsis patients with features of macrophage …
antagonist) in improving 28-day survival in sepsis patients with features of macrophage …
Benefit of anakinra in treating pediatric secondary hemophagocytic lymphohistiocytosis
Objective To assess the benefit of the recombinant human interleukin‐1 receptor antagonist
anakinra in treating pediatric patients with secondary hemophagocytic lymphohistiocytosis …
anakinra in treating pediatric patients with secondary hemophagocytic lymphohistiocytosis …