Porcine IPEC-J2 intestinal epithelial cells in microbiological investigations

AJ Brosnahan, DR Brown - Veterinary microbiology, 2012 - Elsevier
IPEC-J2 cells are porcine intestinal columnar epithelial cells that were isolated from
neonatal piglet mid-jejunum. This cell line forms polarized monolayers with high …

The function of the cellular prion protein in health and disease

JC Watts, MEC Bourkas, H Arshad - Acta neuropathologica, 2018 - Springer
The essential role of the cellular prion protein (PrP C) in prion disorders such as Creutzfeldt–
Jakob disease is well documented. Moreover, evidence is accumulating that PrP C may act …

Improvement of neuronal cell survival by astrocyte‐derived exosomes under hypoxic and ischemic conditions depends on prion protein

K Guitart, G Loers, F Buck, U Bork, M Schachner… - Glia, 2016 - Wiley Online Library
Prion protein (PrP) protects neural cells against oxidative stress, hypoxia, ischemia, and
hypoglycemia. In the present study we confirm that cultured PrP‐deficient neurons are more …

Current evidence on the transmissibility of chronic wasting disease prions to humans—a systematic review

L Waddell, J Greig, M Mascarenhas… - Transboundary and …, 2018 - Wiley Online Library
A number of prion diseases affect humans, including Creutzfeldt–Jakob disease; most of
these are due to genetic mutations in the affected individual and occur sporadically, but …

Overexpression of PrPc, combined with MGr1‐Ag/37LRP, is predictive of poor prognosis in gastric cancer

L Zhou, Y Shang, C Liu, J Li, H Hu… - … journal of cancer, 2014 - Wiley Online Library
Prion protein (PrPc) has been previously reported to be involved in gastric cancer (GC)
development and progression. However, the association between expression of PrPc and …

Emerging roles of the cellular prion protein (PrPC) and 37/67 kDa laminin receptor (RPSA) interaction in cancer biology

A Limone, V Maggisano, D Sarnataro… - Cellular and Molecular …, 2023 - Springer
The cellular prion protein (PrPC) is well-known for its involvement, under its pathogenic
protease-resistant form (PrPSc), in a group of neurodegenerative diseases, known as prion …

Proteomics approach to identify the interacting partners of cellular prion protein and characterization of Rab7a interaction in neuronal cells

S Zafar, N von Ahsen, M Oellerich, I Zerr… - Journal of proteome …, 2011 - ACS Publications
The present study was undertaken to identify proteins interacting with PrPC that could
provide new insights into its physiological functions and pathological role. Human PrPC was …

LRP/LR Antibody Mediated Rescuing of Amyloid-β-Induced Cytotoxicity is Dependent on PrP c in Alzheimer's Disease

EC Pinnock, K Jovanovic, MG Pinto… - Journal of …, 2016 - content.iospress.com
The neuronal perturbations in Alzheimer's disease are attributed to the formation of
extracellular amyloid-β (Aβ) neuritic plaques, composed predominantly of the neurotoxic Aβ …

Recent advances in the function of the 67 kDa laminin receptor and its targeting for personalized therapy in cancer

A Pesapane, P Ragno, C Selleri… - Current pharmaceutical …, 2017 - ingentaconnect.com
The 67 kDa high affinity laminin receptor (67LR) is a non-integrin cell surface receptor for
laminin, the major component of basement membranes. Interactions between 67LR and …

The 37/67kDa laminin receptor (LR) inhibitor, NSC47924, affects 37/67kDa LR cell surface localization and interaction with the cellular prion protein

D Sarnataro, A Pepe, G Altamura, I De Simone… - Scientific reports, 2016 - nature.com
Abstract The 37/67 kDa laminin receptor (LR) is a non-integrin protein, which binds both
laminin-1 of the extracellular matrix and prion proteins, that hold a central role in prion …