Background Pharmacotherapy provides an option for adults with overweight and obesity to
reduce their bodyweight if lifestyle modifications fail. We summarised the latest evidence for …

Objective To evaluate sodium-glucose cotransporter-2 (SGLT-2) inhibitors and glucagon-
like peptide-1 (GLP-1) receptor agonists in patients with type 2 diabetes at varying …

Background Sarcopenia is a serious public health concern among older adults worldwide.
Exercise is the most common intervention for sarcopenia. This study aimed to compare the …

Objective To compare the effects of treatments for coronavirus disease 2019 (covid-19).
Design Living systematic review and network meta-analysis. Data sources WHO covid-19 …

Objective To determine the relative efficacy of structured named diet and health behaviour
programmes (dietary programmes) for prevention of mortality and major cardiovascular …

This article describes GRADE (grading of recommendations assessment, development and
evaluation) guidance on how to make conclusions from a network meta-analysis of …

Importance Respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory
infection in children younger than 5 years; effective prevention strategies are urgently …

Importance Systemic treatments for atopic dermatitis are being evaluated primarily in
placebo-controlled trials; network meta-analysis can provide relative efficacy and safety …

Importance The effectiveness of triplet therapy compared with androgen pathway inhibitor
(API) doublets in a heterogeneous patient population with metastatic castration-sensitive …

Importance The treatment landscape for advanced hepatocellular carcinoma (HCC) has
recently changed and become relatively confusing. Head-to-head comparisons between …