Regulation of the immune response by the aryl hydrocarbon receptor

C Gutiérrez-Vázquez, FJ Quintana - Immunity, 2018 - cell.com
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that is
activated by small molecules provided by the diet, microorganisms, metabolism, and …

[HTML][HTML] Tapinarof validates the aryl hydrocarbon receptor as a therapeutic target: A clinical review

JI Silverberg, M Boguniewicz, FJ Quintana… - Journal of Allergy and …, 2024 - Elsevier
The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that has wide-
ranging roles, including regulation of inflammation and homeostasis. AhR is not a cell …

Aryl hydrocarbon receptor control of a disease tolerance defence pathway

A Bessede, M Gargaro, MT Pallotta, D Matino… - Nature, 2014 - nature.com
Disease tolerance is the ability of the host to reduce the effect of infection on host fitness.
Analysis of disease tolerance pathways could provide new approaches for treating …

Aryl hydrocarbon receptor promotes IL-10 expression in inflammatory macrophages through Src-STAT3 signaling pathway

J Zhu, L Luo, L Tian, S Yin, X Ma, S Cheng… - Frontiers in …, 2018 - frontiersin.org
The aryl hydrocarbon receptor (AhR) is an important immune regulator with a role in
inflammatory response. However, the role of AhR in IL-10 production by inflammatory …

An overview of aryl hydrocarbon receptor ligands in the Last two decades (2002–2022): A medicinal chemistry perspective

L Lin, Y Dai, Y **a - European Journal of Medicinal Chemistry, 2022 - Elsevier
The aryl hydrocarbon receptor (AhR), discovered 46 years ago, is a transcript factor member
of the basic helix-loop-helix Per-ARNT-SIM (bHLH-PAS) family deeply implicated in health …

Aryl hydrocarbon receptor: The master regulator of immune responses in allergic diseases

F Riaz, F Pan, P Wei - Frontiers in Immunology, 2022 - frontiersin.org
The aryl hydrocarbon receptor (AhR) is a widely studied ligand-activated cytosolic
transcriptional factor that has been associated with the initiation and progression of various …

The AhR twist: ligand-dependent AhR signaling and pharmaco-toxicological implications

E Guyot, A Chevallier, R Barouki, X Coumoul - Drug discovery today, 2013 - Elsevier
The aryl hydrocarbon receptor (AhR) is a transcription factor which is activated by diverse
compounds and regulates the expression of xenobiotic metabolism genes. Recent studies …

[HTML][HTML] Unraveling the differential impact of PAHs and dioxin-like compounds on AKR1C3 reveals the EGFR extracellular domain as a critical determinant of the AHR …

C Vogeley, NC Sondermann, S Woeste… - Environment …, 2022 - Elsevier
Polycyclic aromatic hydrocarbons (PAHs), dioxin-like compounds (DLCs) and structurally-
related environmental pollutants may contribute to the pathogenesis of various diseases and …

The aryl hydrocarbon receptor shapes monocyte transcriptional responses to interleukin-4 by prolonging STAT6 binding to promoters

A de Juan, D Tabtim-On, A Coillard, B Becher… - Science …, 2024 - science.org
Cytokines induce functional and metabolic adaptations in immune cells, typically through
transcriptional responses that can be influenced by other extracellular signals and by …

Plant occurring flavonoids as modulators of the aryl hydrocarbon receptor

E Goya-Jorge, ME Jorge Rodríguez, MSI Veitía… - Molecules, 2021 - mdpi.com
The aryl hydrocarbon receptor (AhR) is a transcription factor deeply implicated in health and
diseases. Historically identified as a sensor of xenobiotics and mainly toxic substances, AhR …