Bladder cancer

L Dyrskjøt, DE Hansel, JA Efstathiou… - Nature Reviews …, 2023 - nature.com
Bladder cancer is a global health issue with sex differences in incidence and prognosis.
Bladder cancer has distinct molecular subtypes with multiple pathogenic pathways …

Spatial biology of cancer evolution

Z Seferbekova, A Lomakin, LR Yates… - Nature Reviews …, 2023 - nature.com
The natural history of cancers can be understood through the lens of evolution given that the
driving forces of cancer development are mutation and selection of fitter clones. Cancer …

Crosstalk of disulfidptosis-related subtypes, establishment of a prognostic signature and immune infiltration characteristics in bladder cancer based on a machine …

S Zhao, L Wang, W Ding, B Ye, C Cheng… - Frontiers in …, 2023 - frontiersin.org
Background Bladder cancer (BLCA) is the most common malignancy of the urinary tract. On
the other hand, disulfidptosis, a mechanism of disulfide stress-induced cell death, is closely …

Y chromosome loss in cancer drives growth by evasion of adaptive immunity

HA Abdel-Hafiz, JM Schafer, X Chen, T ** precision oncology of the future
D Akhoundova, MA Rubin - Cancer Cell, 2022 - cell.com
Next-generation DNA sequencing technology has dramatically advanced clinical oncology
through the identification of therapeutic targets and molecular biomarkers, leading to the …

Spatial multi-omics analyses of the tumor immune microenvironment

WC Hsieh, BR Budiarto, YF Wang, CY Lin… - Journal of Biomedical …, 2022 - Springer
In the past decade, single-cell technologies have revealed the heterogeneity of the tumor-
immune microenvironment at the genomic, transcriptomic, and proteomic levels and have …

[HTML][HTML] Spatial transcriptomics: Technologies, applications and experimental considerations

Y Wang, B Liu, G Zhao, YJ Lee, A Buzdin, X Mu, J Zhao… - Genomics, 2023 - Elsevier
The diverse cell types of an organ have a highly structured organization to enable their
efficient and correct function. To fully appreciate gene functions in a given cell type, one …

The post-chemotherapy changes of tumor physical microenvironment: targeting extracellular matrix to address chemoresistance

Y Li, G **, N Liu, H Guo, F Xu - Cancer Letters, 2024 - Elsevier
The tumor physical microenvironment (TPME) contributes to cancer chemoresistance in both
mechanical and mechanobiological approaches. Along with chemotherapy, the tumor …

Spatial transcriptomics technology in cancer research

Q Yu, M Jiang, L Wu - Frontiers in Oncology, 2022 - frontiersin.org
In recent years, spatial transcriptomics (ST) technologies have developed rapidly and have
been widely used in constructing spatial tissue atlases and characterizing spatiotemporal …