Ferroptosis is triggered by intracellular iron leading to accumulation of lipid peroxidation
consequent promotion of cell death. Cancer cell exhibits ability to evade ferroptosis by …

The NF-κB transcription factor was discovered 30 years ago and has since emerged as the
master regulator of inflammation and immune homeostasis. It achieves this status by means …

Immune cells can protect against tumor progression by killing cancer cells, while aberrant
expression of the immune checkpoint protein PD‐L1 (programmed death ligand 1) in cancer …

P65, a protein subunit of NF-κB, is a widely distributed transcription factor in eukaryotic cells
and exerts diverse regulatory functions. Post-translational modifications such as …

Nuclear factor (NF)-κB has evolved as a latent, inducible family of transcription factors
fundamental in the control of the inflammatory response. The transcription of hundreds of …

Regulatory functions of the ubiquitin-proteasome system (UPS) are exercised mainly by the
ubiquitin ligases and deubiquitinating enzymes. Degradation of apoptotic proteins by UPS is …

Cisplatin-induced acute kidney injury (AKI) has been recognized as one of cisplatin's
serious side effects, limiting its use in cancer therapy. Sirtuin 1 (SIRT1) and SIRT3 play …

Calcium and cadmium are divalent metals and have similar chemical properties. Both can
enter cells through, albeit different, channels, or through protein-dependent permeation …

The proteasome inhibitors Bortezomib (BZM) and MG132 trigger cancer cell death via
induction of endoplasmic reticulum (ER) stress and unfolded protein response …

Activation of NF-κB transcription factor is strictly regulated to prevent excessive inflammatory
responses leading to immunopathology. However, it still remains unclear how NF-κB …