The importance of glycans of viral and host proteins in enveloped virus infection
Y Li, D Liu, Y Wang, W Su, G Liu, W Dong - Frontiers in Immunology, 2021 - frontiersin.org
Animal viruses are parasites of animal cells that have characteristics such as heredity and
replication. Viruses can be divided into non-enveloped and enveloped viruses if a lipid …
replication. Viruses can be divided into non-enveloped and enveloped viruses if a lipid …
Antibodies in HIV-1 vaccine development and therapy
F Klein, H Mouquet, P Dosenovic, JF Scheid, L Scharf… - Science, 2013 - science.org
Despite 30 years of study, there is no HIV-1 vaccine and, until recently, there was little hope
for a protective immunization. Renewed optimism in this area of research comes in part from …
for a protective immunization. Renewed optimism in this area of research comes in part from …
[HTML][HTML] Learning from prepandemic data to forecast viral escape
Effective pandemic preparedness relies on anticipating viral mutations that are able to
evade host immune responses to facilitate vaccine and therapeutic design. However, current …
evade host immune responses to facilitate vaccine and therapeutic design. However, current …
[HTML][HTML] Identification of a CD4-binding-site antibody to HIV that evolved near-pan neutralization breadth
Detailed studies of the broadly neutralizing antibodies (bNAbs) that underlie the best
available examples of the humoral immune response to HIV are providing important …
available examples of the humoral immune response to HIV are providing important …
HIV‐1 neutralizing antibodies: understanding nature's pathways
JR Mascola, BF Haynes - Immunological reviews, 2013 - Wiley Online Library
The development of an effective vaccine has been hindered by the enormous diversity of
human immunodeficiency virus‐1 (HIV‐1) and its ability to escape a myriad of host immune …
human immunodeficiency virus‐1 (HIV‐1) and its ability to escape a myriad of host immune …
Virologic effects of broadly neutralizing antibody VRC01 administration during chronic HIV-1 infection
Passive immunization with HIV-1–neutralizing monoclonal antibodies (mAbs) is being
considered for prevention and treatment of HIV-1 infection. As therapeutic agents, mAbs …
considered for prevention and treatment of HIV-1 infection. As therapeutic agents, mAbs …
Broadly neutralizing antibody responses in a large longitudinal sub-Saharan HIV primary infection cohort
E Landais, X Huang, C Havenar-Daughton… - PLoS …, 2016 - journals.plos.org
Broadly neutralizing antibodies (bnAbs) are thought to be a critical component of a
protective HIV vaccine. However, designing vaccines immunogens able to elicit bnAbs has …
protective HIV vaccine. However, designing vaccines immunogens able to elicit bnAbs has …
Broadly neutralizing antibodies and the search for an HIV-1 vaccine: the end of the beginning
PD Kwong, JR Mascola, GJ Nabel - Nature Reviews Immunology, 2013 - nature.com
The field of HIV-1 vaccine research has seen a renaissance with the identification of
antibodies that neutralize most circulating HIV-1 strains. An understanding of the structural …
antibodies that neutralize most circulating HIV-1 strains. An understanding of the structural …
Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120
A substantial proportion of the broadly neutralizing antibodies (bnAbs) identified in certain
HIV-infected donors recognize glycan-dependent epitopes on HIV-1 gp120. Here we …
HIV-infected donors recognize glycan-dependent epitopes on HIV-1 gp120. Here we …
Holes in the glycan shield of the native HIV envelope are a target of trimer-elicited neutralizing antibodies
LE McCoy, MJ van Gils, G Ozorowski, T Messmer… - Cell reports, 2016 - cell.com
A major advance in the search for an HIV vaccine has been the development of a near-
native Envelope trimer (BG505 SOSIP. 664) that can induce robust autologous Tier 2 …
native Envelope trimer (BG505 SOSIP. 664) that can induce robust autologous Tier 2 …