Depressive disorders are among the leading causes of global disease burden, but there has
been limited progress in understanding the causes of and treatments for these disorders. In …

The wide variety of “third wave” cognitive behavioral therapy (CBT) methods (eg,
Acceptance and Commitment Therapy or “ACT”, Compassion Focused Therapy, Meta …

Mental disorder classification provides a definitional framework that underlies applied
clinical and research efforts to understand, assess, predict, prevent and ameliorate the …

Despite a longstanding and widespread influence of the diagnostic approach to mental ill
health, there is an emerging and growing consensus that such psychiatric nosologies may …

The COVID-19 pandemic has potentially increased the risk for adolescent depression. Even
pre-pandemic,< 50% of youth with depression accessed care, highlighting needs for …

Physical activity can treat and prevent depressive symptoms, but its antidepressant
mechanisms are yet to be established. In this review, we comprehensively assess key …

For almost half a century, Paul Meehl educated psychologists about how the mindless use of
null-hypothesis significance tests made research on theories in the social sciences basically …

Chronic stress and depressive-like behaviors in basic neuroscience research have been
associated with impairments of neuroplasticity, such as neuronal atrophy and synaptic loss …

Importance Identifying neurobiological differences between patients with major depressive
disorder (MDD) and healthy individuals has been a mainstay of clinical neuroscience for …

Informatics paradigms for brain and mental health research have seen significant advances
in recent years. These developments can largely be attributed to the emergence of new …