[HTML][HTML] Phage therapy: From biological mechanisms to future directions

SA Strathdee, GF Hatfull, VK Mutalik, RT Schooley - Cell, 2023 - cell.com
Increasing antimicrobial resistance rates have revitalized bacteriophage (phage) research,
the natural predators of bacteria discovered over 100 years ago. In order to use phages …

Macrophage polarization and its role in liver disease

C Wang, C Ma, L Gong, Y Guo, K Fu, Y Zhang… - Frontiers in …, 2021 - frontiersin.org
Macrophages are important immune cells in innate immunity, and have remarkable
heterogeneity and polarization. Under pathological conditions, in addition to the resident …

Hepatic fibrosis 2022: Unmet needs and a blueprint for the future

SL Friedman, M Pinzani - Hepatology, 2022 - Wiley Online Library
Steady progress over four decades toward understanding the pathogenesis and clinical
consequences of hepatic fibrosis has led to the expectation of effective antifibrotic drugs, yet …

Interaction between microbiota and immunity in health and disease

D Zheng, T Liwinski, E Elinav - Cell research, 2020 - nature.com
The interplay between the commensal microbiota and the mammalian immune system
development and function includes multifold interactions in homeostasis and disease. The …

Gut microbiota and human NAFLD: disentangling microbial signatures from metabolic disorders

J Aron-Wisnewsky, C Vigliotti, J Witjes, P Le… - Nature Reviews …, 2020 - nature.com
Gut microbiota dysbiosis has been repeatedly observed in obesity and type 2 diabetes
mellitus, two metabolic diseases strongly intertwined with non-alcoholic fatty liver disease …

The intestinal microbiota fuelling metabolic inflammation

H Tilg, N Zmora, TE Adolph, E Elinav - Nature Reviews Immunology, 2020 - nature.com
Low-grade inflammation is the hallmark of metabolic disorders such as obesity, type 2
diabetes and nonalcoholic fatty liver disease. Emerging evidence indicates that these …

From NASH to HCC: current concepts and future challenges

QM Anstee, HL Reeves, E Kotsiliti, O Govaere… - Nature reviews …, 2019 - nature.com
Caloric excess and sedentary lifestyle have led to a global epidemic of obesity and
metabolic syndrome. The hepatic consequence of metabolic syndrome and obesity …

Intestinal microbiota-derived short chain fatty acids in host health and disease

J Cong, P Zhou, R Zhang - Nutrients, 2022 - mdpi.com
Intestinal microbiota has its role as an important component of human physiology. It
produces metabolites that module key functions to establish a symbiotic crosstalk with their …

Effect of green-Mediterranean diet on intrahepatic fat: the DIRECT PLUS randomised controlled trial

AY Meir, E Rinott, G Tsaban, H Zelicha, A Kaplan… - Gut, 2021 - gut.bmj.com
Objective To examine the effectiveness of green-Mediterranean (MED) diet, further restricted
in red/processed meat, and enriched with green plants and polyphenols on non-alcoholic …

Mechanisms of fibrosis development in nonalcoholic steatohepatitis

RF Schwabe, I Tabas, UB Pajvani - Gastroenterology, 2020 - Elsevier
Nonalcoholic fatty liver disease is the most prevalent liver disease worldwide, affecting 20%–
25% of the adult population. In 25% of patients, nonalcoholic fatty liver disease progresses …