Decades of research have identified genetic factors and biochemical pathways involved in
neurodegenerative diseases (NDDs). We present evidence for the following eight hallmarks …

Biomarkers of neurodegeneration and neuronal injury have the potential to improve
diagnostic accuracy, disease monitoring, prognosis, and measure treatment efficacy …

The recent introduction of new-generation immunoassay methods allows the reliable
quantification of structural brain markers in peripheral matrices. Neurofilament light chain …

Neurofilaments (NFs) are unique among tissue-specific classes of intermediate filaments
(IFs) in being heteropolymers composed of four subunits (NF-L [neurofilament light]; NF-M …

Two complementary approaches were used in search of the intracellular targets of the toxic
PR poly-dipeptide encoded by the repeat sequences expanded in the C9orf72 form of …

The intracellular transport of organelles along an axon is crucial for the maintenance and
function of a neuron. Anterograde axonal transport has a role in supplying proteins and …

Because of the extremely polarized morphology, the proper functioning of neurons largely
relies on the efficient cargo transport along the axon. Axonal transport defects have been …

Essential tremor (ET) is the most common tremor disorder globally and is characterized by
kinetic tremor of the upper limbs, although other clinical features can also occur. Postmortem …

Adult-onset neurodegenerative disorders are disabling and often fatal diseases of the
nervous system whose underlying mechanisms of cell death remain unknown. Defects in …

Many major human neurodegenerative diseases, including Alzheimer's disease,
Parkinson's disease, and amyotrophic lateral sclerosis (ALS), display axonal pathologies …