Due to a lack of novel therapies and biomarkers, the clinical outcomes of osteosarcoma
patients have not significantly improved for decades. The advancement of mass …

This study aimed to investigate the dysregulated proteins and the underlying mechanisms of
gastric precancerous lesions. Proteomic and phosphoproteomic methods were used to …

Selective neuronal vulnerability (SNV) of specific neuroanatomical regions such as frontal
cortex (FC) and hippocampus (HC) is characteristic of age-associated neurodegenerative …

This study sought to identify the mechanism underlying the response to chitosan at the
posttranslational level. Khao Dawk Mali 105 seeds were soaked in 40 mg l− 1 of chitosan …

Search for ideal compounds with known pathways of anticancer mechanism is still a priority
research focus for cancer, as it continues to be a major health challenge across the globe …

Apatinib is known to be a highly selective vascular endothelial growth factor receptor 2
(VEGFR2) inhibitor with anti-angiogenic and anti-tumor properties. In a phase III study, the …

Cisplatin-based concurrent chemoradiotherapy (CCRT) is the standard treatment for cervical
patients with locally advanced disease. Despite the improved survival rates and prognosis …

Purpose Advanced gall bladder cancer (GBC) is an aggressive disease, and there is no
consensus on treatment options beyond first-line chemotherapy. We report a case of an …

Apogossypolone (ApoG2), a novel derivative of gossypol lacking of two aldehyde groups,
exhibits anti-tumor effects. However, the mechanisms by which ApoG2 regulates cervical …

蛋白质磷酸化作为一种最普遍和最重要的翻译后修饰调控着几乎所有的生命过程.
随着高效富集方法和生物质谱技术的快速发展, 低丰度的蛋白质 O-磷酸化修饰获得了规模化 …