Galectins as modulators of tumour progression

FT Liu, GA Rabinovich - Nature Reviews Cancer, 2005 - nature.com
Galectins are a family of animal lectins with diverse biological activities. They function both
extracellularly, by interacting with cell-surface and extracellular matrix glycoproteins and …

Galectin-3: an open-ended story

J Dumic, S Dabelic, M Flögel - … et Biophysica Acta (BBA)-General Subjects, 2006 - Elsevier
Galectins, an ancient lectin family, are characterized by specific binding of β-galactosides
through evolutionary conserved sequence elements of carbohydrate-recognition domain …

[HTML][HTML] Galectin 3 as a guardian of the tumor microenvironment

PP Ruvolo - Biochimica et Biophysica Acta (BBA)-Molecular Cell …, 2016 - Elsevier
Galectin 3 is a member of a family of β-galactoside binding proteins and has emerged as an
important regulator of diverse functions critical in cancer biology including apoptosis …

Novel galectin-3 roles in neurogenesis, inflammation and neurological diseases

LC Soares, O Al-Dalahmah, J Hillis, CC Young, I Asbed… - Cells, 2021 - mdpi.com
Galectin-3 (Gal-3) is an evolutionarily conserved and multifunctional protein that drives
inflammation in disease. Gal-3's role in the central nervous system has been less studied …

Galectin-3 in angiogenesis and metastasis

T Funasaka, A Raz, P Nangia-Makker - Glycobiology, 2014 - academic.oup.com
Galectin-3 is a member of the family of β-galactoside-binding lectins characterized by
evolutionarily conserved sequences defined by structural similarities in their carbohydrate …

Extracellular functions of galectin-3

J Ochieng, V Furtak, P Lukyanov - Glycoconjugate journal, 2002 - Springer
Galectin-3 has been suspected of modulating cell to extracellular matrix interactions in a
novel fashion ever since it was first described. However, the rapid accumulation of research …

Extracellular galectin-3 in tumor progression and metastasis

A Fortuna-Costa, AM Gomes, EO Kozlowski… - Frontiers in …, 2014 - frontiersin.org
Galectin-3, the only chimera galectin found in vertebrates, is one of the best-studied
galectins. It is expressed in several cell types and is involved in a broad range of …

Galectin-3: therapeutic targeting in liver disease

AC Mackinnon, D Tonev, B Jacoby… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction The rising incidence of liver diseases is a worldwide healthcare concern.
However, the therapeutic options to manage chronic inflammation and fibrosis, the …

Galectins and cancer

A Danguy, I Camby, R Kiss - Biochimica et Biophysica Acta (BBA)-General …, 2002 - Elsevier
The galectins are a family of proteins that are distributed widely in all living organisms. All of
them share galactose-specificity. At present, 14 members of the family are characterized in …

Looking into laminin receptor: critical discussion regarding the non‐integrin 37/67‐kDa laminin receptor/RPSA protein

V DiGiacomo, D Meruelo - Biological Reviews, 2016 - Wiley Online Library
ABSTRACT The 37/67‐kDa laminin receptor (LAMR/RPSA) was originally identified as a 67‐
kDa binding protein for laminin, an extracellular matrix glycoprotein that provides cellular …