Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …

Alpha-synuclein (αS) is the major constituent of Lewy bodies and a pathogenic hallmark of
all synucleinopathathies, including Parkinson's disease (PD), dementia with Lewy bodies …

Amyloid beta peptide (Aβ) is produced through the proteolytic processing of a
transmembrane protein, amyloid precursor protein (APP), by β-and γ-secretases. Aβ …

Alzheimer's disease (AD) challenges our society with an annual estimated cost of $1.08
trillion in the United States alone by 2050. 1 AD is a progressive irreversible neurological …

Neurodegenerative disorders and type 2 diabetes are global epidemics compromising the
quality of life of millions worldwide, with profound social and economic implications. Despite …

This review is concerned with the role of fibrillization of the amyloid β (Aβ)-peptide in
Alzheimer's disease (AD). The perspective is that of a physical chemist, and one aim is to …

One of the grand challenges of biophysical chemistry is to understand the principles that
govern protein misfolding and aggregation, which is a highly complex process that is …

Cholesterol has been conjectured to be a modulator of the amyloid cascade, the mechanism
that produces the amyloid-β (Aβ) peptides implicated in the onset of Alzheimer's disease …

Structural studies of Alzheimer's amyloid fibrils have revealed information about the structure
at different levels. The amyloid-β peptide has been examined in various solvents and …

Aggregation of amyloid-β (Aβ) by self-assembly into oligomers or amyloids is a central event
in Alzheimer's disease. Coordination of transition-metal ions, mainly copper and zinc, to Aβ …