The Rise of Boron-Containing Compounds: Advancements in Synthesis, Medicinal Chemistry, and Emerging Pharmacology
Boron-containing compounds (BCC) have emerged as important pharmacophores. To date,
five BCC drugs (including boronic acids and boroles) have been approved by the FDA for …
five BCC drugs (including boronic acids and boroles) have been approved by the FDA for …
Next generation of boron neutron capture therapy (BNCT) agents for cancer treatment
Boron neutron capture therapy (BNCT) is one of the most promising treatments among
neutron capture therapies due to its long‐term clinical application and unequivocally …
neutron capture therapies due to its long‐term clinical application and unequivocally …
A review of boron neutron capture therapy: Its history and current challenges
Abstract Mechanism of Action External beam, whether with photons or particles, remains as
the most common type of radiation therapy. The main drawback is that radiation deposits …
the most common type of radiation therapy. The main drawback is that radiation deposits …
Optimizing boron neutron capture therapy (BNCT) to treat cancer: an updated review on the latest developments on boron compounds and strategies
A Monti Hughes, N Hu - Cancers, 2023 - mdpi.com
Simple Summary Boron neutron capture therapy (BNCT) is a tumor-selective particle
radiotherapy. It combines preferential boron accumulation in tumors and neutron irradiation …
radiotherapy. It combines preferential boron accumulation in tumors and neutron irradiation …
Tumor Eradication by Boron Neutron Capture Therapy with 10B‐enriched Hexagonal Boron Nitride Nanoparticles Grafted with Poly(Glycerol)
Boron neutron capture therapy (BNCT) has emerged as a treatment modality with high
precision and efficacy of intractable tumors. At the core of effective tumor BNCT are 10B …
precision and efficacy of intractable tumors. At the core of effective tumor BNCT are 10B …
Multi-functional boron-delivery agents for boron neutron capture therapy of cancers
Simple Summary Many boron-containing compounds have been synthesized and proposed
as boron-delivery agents for boron neutron capture therapy for cancers, including brain …
as boron-delivery agents for boron neutron capture therapy for cancers, including brain …
Peptide Conjugated Boron Neutron Capture Therapy for Enhanced Tumor Targeting
A cutting-edge non-invasive cancer treatment method called boron neutron capture therapy
(BNCT) allows for the removal of cancerous tumor cells with the least possible damage to …
(BNCT) allows for the removal of cancerous tumor cells with the least possible damage to …
Carboranes as unique pharmacophores in antitumor medicinal chemistry
Y Chen, F Du, L Tang, J Xu, Y Zhao, X Wu, M Li… - Molecular Therapy …, 2022 - cell.com
Carborane is a carbon-boron molecular cluster that can be viewed as a 3D analog of
benzene. It features special physical and chemical properties, and thus has the potential to …
benzene. It features special physical and chemical properties, and thus has the potential to …
Clinical viability of boron neutron capture therapy for personalized radiation treatment
Simple Summary Usually, for dose planning in radiotherapy, the tumor is delimited as a
volume on the image of the patient together with other clinical considerations based on …
volume on the image of the patient together with other clinical considerations based on …
Towards the application of purely inorganic icosahedral boron clusters in emerging nanomedicine
Traditionally, drugs were obtained by extraction from medicinal plants, but more recently
also by organic synthesis. Today, medicinal chemistry continues to focus on organic …
also by organic synthesis. Today, medicinal chemistry continues to focus on organic …