The rise of boron-containing compounds: advancements in synthesis, medicinal chemistry, and emerging pharmacology

RJ Grams, WL Santos, IR Scorei… - Chemical …, 2024 - ACS Publications
Boron-containing compounds (BCC) have emerged as important pharmacophores. To date,
five BCC drugs (including boronic acids and boroles) have been approved by the FDA for …

Next generation of boron neutron capture therapy (BNCT) agents for cancer treatment

P Coghi, J Li, NS Hosmane… - Medicinal Research …, 2023 - Wiley Online Library
Boron neutron capture therapy (BNCT) is one of the most promising treatments among
neutron capture therapies due to its long‐term clinical application and unequivocally …

[HTML][HTML] A review of boron neutron capture therapy: its history and current challenges

WH **, C Seldon, M Butkus, W Sauerwein… - International journal of …, 2022 - Elsevier
Abstract Mechanism of Action External beam, whether with photons or particles, remains as
the most common type of radiation therapy. The main drawback is that radiation deposits …

[HTML][HTML] Optimizing boron neutron capture therapy (BNCT) to treat cancer: An updated review on the latest developments on boron compounds and strategies

A Monti Hughes, N Hu - Cancers, 2023 - mdpi.com
Simple Summary Boron neutron capture therapy (BNCT) is a tumor-selective particle
radiotherapy. It combines preferential boron accumulation in tumors and neutron irradiation …

Tumor Eradication by Boron Neutron Capture Therapy with 10B‐enriched Hexagonal Boron Nitride Nanoparticles Grafted with Poly(Glycerol)

Y Zhang, HG Kang, H Xu, H Luo, M Suzuki… - Advanced …, 2023 - Wiley Online Library
Boron neutron capture therapy (BNCT) has emerged as a treatment modality with high
precision and efficacy of intractable tumors. At the core of effective tumor BNCT are 10B …

Multi-functional boron-delivery agents for boron neutron capture therapy of cancers

SO Oloo, KM Smith, MGH Vicente - Cancers, 2023 - mdpi.com
Simple Summary Many boron-containing compounds have been synthesized and proposed
as boron-delivery agents for boron neutron capture therapy for cancers, including brain …

Peptide Conjugated Boron Neutron Capture Therapy for Enhanced Tumor Targeting

VGSS Jyothi, N Kommineni - Nanotheranostics, 2024 - pmc.ncbi.nlm.nih.gov
A cutting-edge non-invasive cancer treatment method called boron neutron capture therapy
(BNCT) allows for the removal of cancerous tumor cells with the least possible damage to …

Towards the application of purely inorganic icosahedral boron clusters in emerging nanomedicine

F Teixidor, R Núñez, C Viñas - Molecules, 2023 - mdpi.com
Traditionally, drugs were obtained by extraction from medicinal plants, but more recently
also by organic synthesis. Today, medicinal chemistry continues to focus on organic …

Carboranes as unique pharmacophores in antitumor medicinal chemistry

Y Chen, F Du, L Tang, J Xu, Y Zhao, X Wu, M Li… - Molecular Therapy …, 2022 - cell.com
Carborane is a carbon-boron molecular cluster that can be viewed as a 3D analog of
benzene. It features special physical and chemical properties, and thus has the potential to …

[HTML][HTML] Targeting the organelle for radiosensitization in cancer radiotherapy

X Sun, L Wu, L Du, W Xu, M Han - Asian Journal of Pharmaceutical …, 2024 - Elsevier
Radiotherapy is a well-established cytotoxic therapy for local solid cancers, utilizing high-
energy ionizing radiation to destroy cancer cells. However, this method has several …