PGE 2, an essential homeostatic factor, is also a key mediator of immunopathology in
chronic infections and cancer. The impact of PGE 2 reflects the balance between its …

The immunotherapy of cancer has made significant strides in the past few years due to
improved understanding of the underlying principles of tumor biology and immunology …

This review focuses on one family of the known cAMP receptors, the exchange proteins
directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide …

Mucosal surfaces such as the intestinal tract are continuously exposed to both potential
pathogens and beneficial commensal microorganisms. This creates a requirement for a …

This article provides an overview of how intestinal epithelial cells (IEC) recognize
commensals and how they maintain host-bacterial symbiosis. Endocrine, goblet cells, and …

Arachidonic acid (AA)-derived eicosanoids belong to a complex family of lipid mediators that
regulate a wide variety of physiological responses and pathological processes. They are …

It has been documented that strenuous exercise not only induces pyrogenesis but also
elicits mobilization and functional augmentation of neutrophils and monocytes whereas it …

Tolerogenic dendritic cells (tDC) are a promising tool for specific cellular therapy to induce
immunological tolerance in transplantation and autoimmunity. To date, most described tDC …

Typical immune responses lead to prominent clonal expansion of antigen-specific T and B
cells followed by differentiation into effector cells. Most effector cells die at the end of the …

Dendritic cells (DCs) are potent antigen-presenting cells that are able to initiate and
modulate immune responses and are hence exploited as cellular vaccines for …