PIWI-interacting RNAs (piRNAs) are a class of small non-coding RNAs that associate with
proteins of the PIWI clade of the Argonaute family. First identified in animal germ line cells …

Deep Learning (DL) has recently enabled unprecedented advances in one of the grand
challenges in computational biology: the half-century-old problem of protein structure …

The depletion of disruptive variation caused by purifying natural selection (constraint) has
been widely used to investigate protein-coding genes underlying human disorders,,–, but …

Tobacco and alcohol use are heritable behaviours associated with 15% and 5.3% of
worldwide deaths, respectively, due largely to broad increased risk for disease and injury …

Tissue regeneration requires coordination between resident stem cells and local niche
cells,. Here we identify that senescent cells are integral components of the skeletal muscle …

Histopathology image evaluation is indispensable for cancer diagnoses and subtype
classification. Standard artificial intelligence methods for histopathology image analyses …

Ferroptosis is a mode of regulated cell death characterized by iron-dependent accumulation
of lipid peroxidation. It is closely linked to the pathophysiological processes in many …

Predicting the effects of coding variants is a major challenge. While recent deep-learning
models have improved variant effect prediction accuracy, they cannot analyze all coding …

IgA nephropathy (IgAN) is a progressive form of kidney disease defined by glomerular
deposition of IgA. Here we performed a genome-wide association study of 10,146 kidney …

Computational pathology can lead to saving human lives, but models are annotation hungry
and pathology images are notoriously expensive to annotate. Self-supervised learning has …