The dopamine hypothesis is the longest standing pathoetiologic theory of schizophrenia.
Because it was initially based on indirect evidence and findings in patients with established …

Context During the past 2 decades, a major transition in the clinical characterization of
psychotic disorders has occurred. The construct of a clinical high-risk (HR) state for …

Objective: Approximately 20%–35% of individuals 12–35 years old who meet criteria for a
prodromal risk syndrome convert to psychosis within 2 years. However, this estimate ignores …

There is a growing understanding that pathological genetic variation and environmental
insults during sensitive periods in brain development have long-term consequences on …

Context A substantial proportion of people at clinical high risk of psychosis will develop a
psychotic disorder over time. However, the risk of transition to psychosis varies between …

Over the past decade, our understanding of the role of stress in serious mental illness has
become more sophisticated. In this paper, we revisit the neural diathesis-stress model of …

Introduction Antipsychotics (AP) induce weight gain. However, reviews and meta-analyses
generally are restricted to second generation antipsychotics (SGA) and do not stratify for …

Despite a lack of recent progress in the treatment of schizophrenia, our understanding of its
genetic and environmental causes has considerably improved, and their relationship to …

This guidance paper from the European Psychiatric Association (EPA) aims to provide
evidence-based recommendations on early intervention in clinical high risk (CHR) states of …

Objective To determine whether any psychological, pharmacological, or nutritional
interventions can prevent or delay transition to psychotic disorders for people at high risk …