Multiplicity of cerebrospinal fluid functions: New challenges in health and disease
This review integrates eight aspects of cerebrospinal fluid (CSF) circulatory dynamics:
formation rate, pressure, flow, volume, turnover rate, composition, recycling and …
formation rate, pressure, flow, volume, turnover rate, composition, recycling and …
The divergence, actions, roles, and relatives of sodium-coupled bicarbonate transporters
MD Parker, WF Boron - Physiological reviews, 2013 - journals.physiology.org
The mammalian Slc4 (Solute carrier 4) family of transporters is a functionally diverse group
of 10 multi-spanning membrane proteins that includes three Cl-HCO3 exchangers (AE1–3) …
of 10 multi-spanning membrane proteins that includes three Cl-HCO3 exchangers (AE1–3) …
The Na+-dependent chloride-bicarbonate exchanger SLC4A8 mediates an electroneutral Na+ reabsorption process in the renal cortical collecting ducts of mice
Regulation of sodium balance is a critical factor in the maintenance of euvolemia, and
dysregulation of renal sodium excretion results in disorders of altered intravascular volume …
dysregulation of renal sodium excretion results in disorders of altered intravascular volume …
Intracellular pH regulation by acid-base transporters in mammalian neurons
Intracellular pH (pHi) regulation in the brain is important in both physiological and
physiopathological conditions because changes in pHi generally result in altered neuronal …
physiopathological conditions because changes in pHi generally result in altered neuronal …
Intracellular pH regulation in heart
Intracellular pH (pHi) is an important modulator of cardiac excitation and contraction, and a
potent trigger of electrical arrhythmia. This review outlines the intracellular and membrane …
potent trigger of electrical arrhythmia. This review outlines the intracellular and membrane …
Regulation and roles of bicarbonate transporters in cancer
A unifying feature of solid tumors is a markedly altered pH profile compared to normal
tissues. This reflects that solid tumors, despite completely different origins, often share …
tissues. This reflects that solid tumors, despite completely different origins, often share …
Physiology, pharmacology and pathophysiology of the pH regulatory transport proteins NHE1 and NBCn1: similarities, differences, and implications for cancer therapy
The Na+/H+-exchanger 1, NHE1 (SLC9A1) and the electroneutral Na+, HCO3--
cotransporter NBCn1 (SLC4A7) are coexpressed in a wide range of tissues. Under normal …
cotransporter NBCn1 (SLC4A7) are coexpressed in a wide range of tissues. Under normal …
Disruption of Na+,HCO3− Cotransporter NBCn1 (slc4a7) Inhibits NO-Mediated Vasorelaxation, Smooth Muscle Ca2+ Sensitivity, and Hypertension Development in …
Background—Disturbances in pH affect artery function, but the mechanistic background
remains controversial. We investigated whether Na+, HCO3− cotransporter NBCn1, by …
remains controversial. We investigated whether Na+, HCO3− cotransporter NBCn1, by …
Contribution of Na+,HCO3−‐cotransport to cellular pH control in human breast cancer: A role for the breast cancer susceptibility locus NBCn1 (SLC4A7)
Genome‐wide association studies recently linked the locus for Na+, HCO3−‐cotransporter
NBCn1 (SLC4A7) to breast cancer susceptibility, yet functional insights have been lacking …
NBCn1 (SLC4A7) to breast cancer susceptibility, yet functional insights have been lacking …
The physiology of bicarbonate transporters in mammalian reproduction
HCO3–plays critically important roles during virtually the entire process of reproduction in
mammals, including spermatogenesis, sperm capacitation, fertilization, and development of …
mammals, including spermatogenesis, sperm capacitation, fertilization, and development of …