Obesity has been described as a global epidemic and is a low-grade chronic inflammatory
disease that arises as a consequence of energy imbalance. Obesity increases the risk of …

A growing body of evidence highlights the close association between nutrition and human
health. Fat is an essential macronutrient, and vegetable oils, such as palm oil, are widely …

Metabolic rewiring is often considered an adaptive pressure limiting metastasis formation;
however, some nutrients available at distant organs may inherently promote metastatic …

The notion that electrophiles serve as messengers in cell signaling is now widely accepted.
Nonetheless, major issues restrain acceptance of redox homeostasis and redox signaling as …

Low-grade inflammation is a characteristic of the obese state, and adipose tissue releases
many inflammatory mediators. The source of these mediators within adipose tissue is not …

Hepatocellular carcinoma (HCC) is the second-leading cause of cancer-related death
worldwide and the factors influencing HCC progression are poorly understood. Here we …

TLR4 is the receptor for LPS and plays a critical role in innate immunity. Stimulation of TLR4
activates proinflammatory pathways and induces cytokine expression in a variety of cell …

Obesity is a major risk factor for the development of various pathological conditions
including insulin resistance, diabetes, cardiovascular diseases, and non-alcoholic fatty liver …

Endothelial dysfunction contributes to cardiovascular diseases, including hypertension,
atherosclerosis, and coronary artery disease, which are also characterized by insulin …

Inflammation is associated with a number of chronic conditions, such as cancer and
cardiovascular disease. Reducing inflammation may help prevent or treat these conditions …