[HTML][HTML] Neuroprotection in glaucoma: mechanisms beyond intraocular pressure lowering

JR Tribble, F Hui, H Quintero, S El Hajji, K Bell… - Molecular aspects of …, 2023 - Elsevier
Glaucoma is a common, complex, multifactorial neurodegenerative disease characterized
by progressive dysfunction and then loss of retinal ganglion cells, the output neurons of the …

Rapid assessment of ocular toxicity from environmental contaminants based on visually mediated zebrafish behavior studies

J Yi, Y Ma, J Ma, H Yu, K Zhang, L **, Q Yang, D Sun… - Toxics, 2023 - mdpi.com
The presence of contaminants in the environment has increased in recent years, and studies
have demonstrated that these contaminants have the ability to penetrate the blood–retinal …

Aldose reductase inhibition decelerates optic nerve degeneration by alleviating retinal microglia activation

M Rao, YK Huang, CC Liu, C Meadows, HC Cheng… - Scientific Reports, 2023 - nature.com
As part of the central nervous system (CNS), retinal ganglion cells (RGCs) and their axons
are the only neurons in the retina that transmit visual signals from the eye to the brain via the …

Zebrafish models for the safety and therapeutic testing of nanoparticles with a focus on macrophages

A Pensado-López, J Fernández-Rey, P Reimunde… - Nanomaterials, 2021 - mdpi.com
New nanoparticles and biomaterials are increasingly being used in biomedical research for
drug delivery, diagnostic applications, or vaccines, and they are also present in numerous …

Zebrafish model in ophthalmology to study disease mechanism and drug discovery

Y Hong, Y Luo - Pharmaceuticals, 2021 - mdpi.com
Visual impairment and blindness are common and seriously affect people's work and quality
of life in the world. Therefore, the effective therapies for eye diseases are of high priority …

Are Hyperglycemia-Induced changes in the Retina Associated with Diabetes-correlated changes in the brain? A review from zebrafish and rodent type 2 diabetes …

K Augustine-Wofford, VP Connaughton, E McCarthy - Biology, 2024 - mdpi.com
Simple Summary Diabetes is a worldwide epidemic that affects the retina, kidneys, and
peripheral nerves. More recent findings indicate that brain changes also occur and are …

Application of stem cells, growth factors, small molecules, and biological macromolecules on nerve regeneration: a review and future direction

S Nemati Mahand, N Niknami… - … Journal of Polymeric …, 2024 - Taylor & Francis
The nervous system is a vital component of the human body, and its dysfunction can have
fatal consequences or severe adverse effects. After significant disabling conditions, the …

An overview towards zebrafish larvae as a model for ocular diseases

JGS Rosa, M Lopes-Ferreira, C Lima - International Journal of Molecular …, 2023 - mdpi.com
Despite the obvious morphological differences in the visual system, zebrafish share a similar
architecture and components of the same embryonic origin as humans. The zebrafish retina …

Disrupting the Repeat Domain of Premelanosome Protein (PMEL) Produces Dysamyloidosis and Dystrophic Ocular Pigment Reflective of Pigmentary Glaucoma

ED Hodges, PW Chrystal, T Footz, LP Doucette… - International Journal of …, 2023 - mdpi.com
Pigmentary glaucoma has recently been associated with missense mutations in PMEL that
are dominantly inherited and enriched in the protein's fascinating repeat domain. PMEL …

NCS1 overexpression restored mitochondrial activity and behavioral alterations in a zebrafish model of Wolfram syndrome

L Crouzier, EM Richard, C Diez, M Denus… - … Therapy-Methods & …, 2022 - cell.com
Wolfram syndrome (WS) is a rare neurodegenerative disease resulting in deafness, optic
atrophy, diabetes, and neurological disorders. Currently, no treatment is available for …