Osteosarcoma is the most common primary bone malignancy in adolescents. Its high
propensity to metastasize is the leading cause for treatment failure and poor prognosis …

Abstract CCN1 (CYR61) is a dynamically expressed, multifunctional matricellular protein
that plays essential roles in cardiovascular development during embryogenesis, and …

Abstract Hypoxia-inducible factor 1 (HIF-1) activates transcription of genes encoding
angiogenic growth factors, which are secreted by hypoxic cells and stimulate endothelial …

Members of the CCN (CYR61/CTGF/NOV) family have emerged as dynamically expressed,
extracellular matrix-associated proteins that play critical roles in cardiovascular and skeletal …

Affymetrix and spotted oligonucleotide microarrays were used to assess global differential
gene expression comparing normal human melanocytes with six independent melanoma …

Hypoxia is a physiologically important endoplasmic reticulum (ER) stress that is present in
all solid tumors. Numerous clinical studies have shown that tumor hypoxia predicts for …

Solid tumors possess malformed vasculature that results in the exposure of tumor cells to a
low oxygen environment. Tumor hypoxia has been demonstrated in human and mouse …

Tumor microenvironment controls the selection of malignant cells capable of surviving in
stressful and hypoxic conditions. The transcription factor, cyclic AMP-responsive element …

Hippo was first identified in a genetic screen as a protein that suppressed proliferation and
cell growth. Subsequently, it was shown that hippo acted in a so-called canonical cascade to …

Circular RNAs (circRNAs) are emerging regulators in the development of human cancers.
However, the role of circRNAs in melanoma is poorly understood. Microarray analysis and …