Widespread clinical laboratory implementation of next-generation sequencing–based
cancer testing has highlighted the importance and potential benefits of standardizing the …

A pan-genome is the nonredundant collection of genes and/or DNA sequences in a species.
Numerous studies have shown that plant pan-genomes are typically much larger than the …

Systematic understanding of immune aging on a whole-body scale is currently lacking. We
characterized age-associated alterations in immune cells across multiple mouse organs …

Abstract Around 30–40% of patients with colorectal cancer (CRC) undergoing curative
resection of the primary tumour will develop metastases in the subsequent years. Therapies …

SARS-CoV-2 uses angiotensin-converting enzyme 2 (ACE2) as its cellular receptor, as do
SARS-CoV and the coronavirus NL63. 1 Higher ACE2 expression increases in vitro …

The African continent is regarded as the cradle of modern humans and African genomes
contain more genetic variation than those from any other continent, yet only a fraction of the …

Abstract Ensembl Genomes (http://www. ensemblgenomes. org) is an integrating resource
for genome-scale data from non-vertebrate species, complementing the resources for …

Synapses are fundamental information-processing units of the brain, and synaptic
dysregulation is central to many brain disorders (" synaptopathies"). However, systematic …

Background RNA-seq is widely used for transcriptomic profiling, but the bioinformatics
analysis of resultant data can be time-consuming and challenging, especially for biologists …

Natural genetic variation in the human genome is a cause of individual differences in
responses to medications and is an underappreciated burden on public health. Although …