Purpose To summarize the microstructure–property relationship of pharmaceutical tablets
and approaches to improve tablet properties through tablet microstructure engineering …

The internal microstructure of a tablet, such as pore geometry and pore volume, impacts the
tablet's disintegration kinetics. Ideally, one could design the microstructure to control …

We use dynamic micro-computed tomography (micro-CT) with a high temporal resolution to
visualize water penetration through the porous network of immediate-release …

Compaction of granular powders underpins many engineering and industrial processes.
The physics underlying the compaction process of highly deformable, cohesive granular …

We formulate a discrete Lagrangian model for a set of interacting grains, which is purely
elastic. The considered degrees of freedom for each grain include placement of barycenter …

During early drug product development, methods for characterization of mechanical
attributes are developed for flat, round tablets. However, there is a lack of understanding on …

A micro-mechanical model devoted to study large deformations of cohesive granular media
subjected to quasi-static external actions is presented and discussed. The model, leaving …

We present generalized loading-unloading contact laws for elasto-plastic spheres with
bonding strength. The proposed mechanistic contact laws are continuous at the onset of …

A particle model devoted to the study of three-dimensional grain packages in a dynamic
setting is presented and discussed. The proposed approach considers each grain as a rigid …

We adopt a Quality by Design (QbD) paradigm to better control the mechanical properties of
tablets. To this end, the effect of particle size distribution, lubricant concentration, and mixing …