Dystrophin-and utrophin-based therapeutic approaches for treatment of duchenne muscular dystrophy: a comparative review

S Szwec, Z Kapłucha, JS Chamberlain, P Konieczny - BioDrugs, 2024 - Springer
Duchenne muscular dystrophy is a devastating disease that leads to progressive muscle
loss and premature death. While medical management focuses mostly on symptomatic …

Dystrophin S3059 phosphorylation partially attenuates denervation atrophy in mouse tibialis anterior muscles

K Swiderski, T Naim, J Trieu, A Chee… - Physiological …, 2024 - Wiley Online Library
The dystrophin protein has well‐characterized roles in force transmission and maintaining
membrane integrity during muscle contraction. Studies have reported decreased expression …

[HTML][HTML] Altering phosphorylation of dystrophin S3059 to attenuate cancer cachexia

K Swiderski, J Trieu, A Chee, T Naim, CJ Brock… - Life Sciences, 2025 - Elsevier
Aims Cancer cachexia affects up to 80% of patients with advanced cancer and accounts for>
20% of all cancer-related deaths. Sarcolemmal localization of dystrophin, a key protein …

Two operational modes of atomic force microscopy reveal similar mechanical properties for homologous regions of dystrophin and utrophin

C Hua, RA Slick, J Vavra, JM Muretta, JM Ervasti… - bioRxiv, 2024 - biorxiv.org
Duchenne muscular dystrophy (DMD) is a lethal muscle disease caused by the absence of
the protein dystrophin. Dystrophin is hypothesized to work as a molecular shock absorber …

Identifying single molecule force spectroscopy data using deep learning with physics augmentation

C Hua - openreview.net
Deciphering the pathways of protein folding and unfolding under tension is essential for
deepening our understanding of fundamental biological mechanisms. Such insights offer the …