Accumulating evidence shows that cellular and acellular components in tumor
microenvironment (TME) can reprogram tumor initiation, growth, invasion, metastasis, and …

The tumor microenvironment (TME) is a complex and ever-changing “rogue organ”
composed of its own blood supply, lymphatic and nervous systems, stroma, immune cells …

State-of-the-art tissue-clearing methods provide subcellular-level optical access to intact
tissues from individual organs and even to some entire mammals. When combined with light …

Tissue clearing of gross anatomical samples was first described more than a century ago
and has only recently found widespread use in the field of microscopy. This renaissance has …

Metastasis has long been understood to lead to the overwhelming majority of cancer-related
deaths. However, our understanding of the metastatic process, and thus our ability to …

Obesity is often associated with a chronic, low-grade inflammatory state affecting the entire
body. This sustained inflammatory state disrupts the coordinated communication between …

Homeostatic and pathological phenomena often affect multiple organs across the whole
organism. Tissue clearing methods, together with recent advances in microscopy, have …

Cell migration and invasiveness significantly contribute to desirable physiological
processes, such as wound healing or embryogenesis, as well as to serious pathological …

To comprehensively understand tissue and organism physiology and pathophysiology, it is
essential to create complete three-dimensional (3D) cellular maps. These maps require …

Simple Summary Pancreatic Ductal Adenocarcinoma (PDAC) remains one of the deadliest
forms of cancer, characterized by high rates of metastasis, late detection, and poor …