Normal hypothalamopituitary development is closely related to that of the forebrain and is
dependent upon a complex genetic cascade of transcription factors and signaling molecules …

The anterior pituitary gland has the ability to respond to complex signals derived from central
and peripheral systems. Perception of these signals and their integration are mediated by …

Expression of the pro-opiomelanocortin (POMC) gene integrates numerous inputs that
reflect the developmental history of POMC-expressing cells of the pituitary and …

Cushing's disease caused due to adrenocorticotropic hormone (ACTH)-secreting pituitary
adenomas (ACTHomas) leads to hypercortisolemia, resulting in increased morbidity and …

The transforming growth factor-β (TGF-β) superfamily is a multifunctional, contextually acting
family of cytokines that participate in the regulation of development, disease and tissue …

Rationale: T-box transcription factors play critical roles in the coordinated formation of the
working chambers and the atrioventricular canal (AVC). Tbx2 patterns embryonic myocardial …

Bone morphogenetic protein (Bmp) signaling is critical for the development and patterning of
the mouse pituitary from the initial induction of Rathke's pouch to cell specification in the …

Transforming growth factors-β (TGF-βs) signal through type I and type II serine–threonine
kinase receptor complexes. During ligand binding, type II receptors recruit and …

The MyoD gene is part of the core regulatory network that governs skeletal myogenesis and
acts as an essential determinant of the myogenic cell fate. Although generic regulatory …

The molecular mechanisms governing the pathogenesis of ACTH-secreting pituitary
adenomas are still obscure. Furthermore, the pharmacological treatment of these tumors is …