Guided nuclear exploration increases CTCF target search efficiency

AS Hansen, A Amitai, C Cattoglio, R Tjian… - Nature chemical …, 2020 - nature.com
The enormous size of mammalian genomes means that for a DNA-binding protein the
number of nonspecific, off-target sites vastly exceeds the number of specific, cognate sites …

Single-molecule imaging of chromatin remodelers reveals role of ATPase in promoting fast kinetics of target search and dissociation from chromatin

JM Kim, P Visanpattanasin, V Jou, S Liu, X Tang… - Elife, 2021 - elifesciences.org
Conserved ATP-dependent chromatin remodelers establish and maintain genome-wide
chromatin architectures of regulatory DNA during cellular lifespan, but the temporal …

[HTML][HTML] Coalescing replication compartments provide the opportunity for recombination between coinfecting herpesviruses

E Tomer, EM Cohen, N Drayman, A Afriat… - The FASEB …, 2019 - pmc.ncbi.nlm.nih.gov
Homologous recombination (HR) is considered a major driving force of evolution because it
generates and expands genetic diversity. Evidence of HR between coinfecting herpesvirus …

Structural and functional characterization of the interaction between influenza polymerase and the cellular transcription machinery

M Lukarska - 2018 - theses.hal.science
Influenza is an infectious disease causing seasonal epidemics and occasional pandemics,
which are a significant health burden for the global human population. The causative agent …

Recombination between co-infecting herpesviruses occurs where replication compartments coalesce

E Tomer, EM Cohen, N Drayman, A Afriaat… - bioRxiv, 2018 - biorxiv.org
Recombination between co-infecting herpesvirus DNA genomes is an important process
affecting viral population diversity and evolution. Each herpes simplex virus type 1 (HSV-1) …