Harnessing the potential of hydrogels for advanced therapeutic applications: Current achievements and future directions

P Lu, D Ruan, M Huang, M Tian, K Zhu… - Signal transduction and …, 2024‏ - nature.com
The applications of hydrogels have expanded significantly due to their versatile, highly
tunable properties and breakthroughs in biomaterial technologies. In this review, we cover …

Harnessing nanomedicine for cartilage repair: design considerations and recent advances in biomaterials

H Zhou, Z Zhang, Y Mu, H Yao, Y Zhang, DA Wang - ACS nano, 2024‏ - ACS Publications
Cartilage injuries are escalating worldwide, particularly in aging society. Given its limited self-
healing ability, the repair and regeneration of damaged articular cartilage remain formidable …

Research progress in hydrogels for cartilage organoids

X Li, S Sheng, G Li, Y Hu, F Zhou… - Advanced Healthcare …, 2024‏ - Wiley Online Library
The repair and regeneration of cartilage has always been a hot topic in medical research.
Cartilage organoids (CORGs) are special cartilage tissue created using tissue engineering …

Type II collagen scaffolds for tissue engineering

X Hu, Z Wu, Z Zhang, H Yao, DA Wang - Communications Materials, 2024‏ - nature.com
Type II collagen (CII), a key component of cartilaginous tissues, offers an attractive option for
fabricating biomimetic scaffolds that provide mechanical support and biochemical signals to …

Gradient scaffolds for osteochondral tissue engineering and regeneration

Z **ong, F Hong, Z Wu, Y Ren, N Sun, BC Heng… - Chemical Engineering …, 2024‏ - Elsevier
In recent years, the incidence of osteoarthritis (OA) has been increasing worldwide. This
disease not only affects the articular cartilage but also impairs the subchondral bone and …

Advances of naturally derived biomedical polymers in tissue engineering

T Hu, J Fang, Y Shen, M Li, B Wang, Z Xu… - Frontiers in Chemistry, 2024‏ - frontiersin.org
The extensive utilization of natural polymers in tissue engineering is attributed to their
excellent biocompatibility, degradability, and resemblance to the natural extracellular matrix …

Materials suitable for osteochondral regeneration

R Novotná, J Franková - ACS omega, 2024‏ - ACS Publications
Osteochondral defects affect articular cartilage, calcified cartilage, and subchondral bone.
The main problem that they cause is a different behavior of cell tissue in the osteochondral …

Glycosphingolipids in Osteoarthritis and Cartilage-Regeneration Therapy: Mechanisms and Therapeutic Prospects Based on a Narrative Review of the Literature

K Homan, T Onodera, M Matsuoka… - International Journal of …, 2024‏ - mdpi.com
Glycosphingolipids (GSLs), a subtype of glycolipids containing sphingosine, are critical
components of vertebrate plasma membranes, playing a pivotal role in cellular signaling …

Collagen Type II-Based Injectable Materials for In situ Repair and Regeneration of Articular Cartilage Defect

Z Zhang, X Hu, M **, Y Mu, H Zhou, C Ma… - Biomaterials …, 2024‏ - spj.science.org
Repairing and regenerating articular cartilage defects (ACDs) have long been challenging
for physicians and scientists. The rise of injectable materials provides a novel strategy for …

Tissue-engineered collagen matrix loaded with rat adipose-derived stem cells/human amniotic mesenchymal stem cells for rotator cuff tendon-bone repair

J Shi, H Yao, H Chong, X Hu, J Yang, X Dai… - International Journal of …, 2024‏ - Elsevier
The rotator cuff tendon-bone interface tissue exhibits high heterogeneity in its composition
and structure, with collagen being its primary component. Here, we prepared tissue …