Pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase (KGDH) are vital entry
points for monosaccharides and amino acids into the Krebs cycle and thus integral for …

The molecular oxygen (O2) paradox was coined to describe its essential nature and toxicity.
The latter characteristic of O2 is associated with the formation of reactive oxygen species …

The oxidation of the Breslow intermediate resulting from the addition of an N-heterocyclic
carbene (NHC) to benzaldehyde triggers a fast deprotonation, followed by a second electron …

In the present study, we examined the mitochondrial hydrogen peroxide (mH 2 O 2)
generating capacity of α-ketoglutarate dehydrogenase (KGDH) and compared it to …

Oxoglutarate dehydrogenase (Ogdh) is an important mitochondria redox sensor that can
undergo S-glutathionylation following an increase in H 2 O 2 levels. Although S …

Individual recombinant components of pyruvate and 2-oxoglutarate dehydrogenase
multienzyme complexes (PDHc, OGDHc) of human and Escherichia coli (E. coli) origin were …

Background The human mitochondrial alpha-ketoglutarate dehydrogenase complex
(hKGDHc) converts KG to succinyl-CoA and NADH. Malfunction of and reactive oxygen …

This review summarizes our present view on the molecular pathogenesis of human (h) E3-
deficiency caused by a variety of genetic alterations with a special emphasis on the …

Herein are reported unique properties of the novel human thiamin diphosphate (ThDP)-
dependent enzyme 2-oxoadipate dehydrogenase (hE1a), known as dehydrogenase E1 and …

α-ketoglutarate dehydrogenase complex (KGDHc), or 2-oxoglutarate dehydrogenase
complex (OGDHc) is a rate-limiting enzyme in the tricarboxylic acid cycle, that has been …