The acute respiratory distress syndrome is a common, devastating clinical syndrome of
acute lung injury that affects both medical and surgical patients. Since the last review of this …

▪ Sepsis and its sequelae (sepsis syndrome and septic shock) are increasingly common and
are still potentially lethal diagnoses. Many mediators of the pathogenesis of sepsis have …

Background Whether hydrocortisone reduces mortality among patients with septic shock is
unclear. Methods We randomly assigned patients with septic shock who were undergoing …

ContextSeptic shock may be associated with relative adrenal insufficiency. Thus, a
replacement therapy of low doses of corticosteroids has been proposed to treat septic shock …

Background Hydrocortisone is widely used in patients with septic shock even though a
survival benefit has been reported only in patients who remained hypotensive after fluid and …

A better understanding of the inflammatory, procoagulant, and immunosuppressive aspects
of sepsis has contributed to rational therapeutic plans. This review considers optimal …

Background Persistent acute respiratory distress syndrome (ARDS) is characterized by
excessive fibroproliferation, ongoing inflammation, prolonged mechanical ventilation, and a …

Septic shock is the commonest cause of death in intensive care units. Although sepsis
usually produces a low systemic vascular resistance and elevated cardiac output, strong …

THE purpose of this review is to evaluate recent developments in our understanding of the
inflammatory response to cardiac surgery. Scientific knowledge in this field is continually …

A further meeting, sponsored by WHO, was held on 4-8 December 1995 in Geneva. The
purpose was to review in great detail the latest scientific evidence for, and practical …