Ferroptosis: molecular mechanisms and health implications

D Tang, X Chen, R Kang, G Kroemer - Cell research, 2021 - nature.com
Cell death can be executed through different subroutines. Since the description of
ferroptosis as an iron-dependent form of non-apoptotic cell death in 2012, there has been …

Necroptosis, pyroptosis and apoptosis: an intricate game of cell death

D Bertheloot, E Latz, BS Franklin - Cellular & molecular immunology, 2021 - nature.com
Cell death is a fundamental physiological process in all living organisms. Its roles extend
from embryonic development, organ maintenance, and aging to the coordination of immune …

Extracellular vesicles and nanoparticles: emerging complexities

DK Jeppesen, Q Zhang, JL Franklin, RJ Coffey - Trends in Cell Biology, 2023 - cell.com
The study of extracellular vesicles (EVs) and nanoparticles (NPs) is rapidly expanding
because recent discoveries have revealed a much greater complexity and diversity than was …

Ferroptosis: machinery and regulation

X Chen, J Li, R Kang, DJ Klionsky, D Tang - Autophagy, 2021 - Taylor & Francis
Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death caused by lipid
peroxidation, which is controlled by integrated oxidation and antioxidant systems. The iron …

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

L Galluzzi, I Vitale, SA Aaronson, JM Abrams… - Cell Death & …, 2018 - nature.com
Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical …

[HTML][HTML] Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease

BR Stockwell, JPF Angeli, H Bayir, AI Bush, M Conrad… - Cell, 2017 - cell.com
Ferroptosis is a form of regulated cell death characterized by the iron-dependent
accumulation of lipid hydroperoxides to lethal levels. Emerging evidence suggests that …

Emerging connectivity of programmed cell death pathways and its physiological implications

S Bedoui, MJ Herold, A Strasser - Nature reviews Molecular cell biology, 2020 - nature.com
The removal of functionally dispensable, infected or potentially neoplastic cells is driven by
programmed cell death (PCD) pathways, highlighting their important roles in homeostasis …

Recent progress in ferroptosis inducers for cancer therapy

C Liang, X Zhang, M Yang, X Dong - Advanced materials, 2019 - Wiley Online Library
Ferroptosis is a newly discovered form of regulated cell death that is the nexus between
metabolism, redox biology, and human health. Emerging evidence shows the potential of …

The molecular machinery of regulated cell death

D Tang, R Kang, TV Berghe, P Vandenabeele… - Cell research, 2019 - nature.com
Cells may die from accidental cell death (ACD) or regulated cell death (RCD). ACD is a
biologically uncontrolled process, whereas RCD involves tightly structured signaling …

Cancer cells dying from ferroptosis impede dendritic cell-mediated anti-tumor immunity

B Wiernicki, S Maschalidi, J Pinney, S Adjemian… - Nature …, 2022 - nature.com
Immunogenic cell death significantly contributes to the success of anti-cancer therapies, but
immunogenicity of different cell death modalities widely varies. Ferroptosis, a form of cell …