Conventional anticancer chemotherapy has been historically thought to act through direct
killing of tumor cells. This concept stems from the fact that cytotoxic drugs interfere with DNA …

The incidence of pancreatic cancer has been increasing while its 5-year survival rate has
not changed in decades. In the era of personalized medicine, immunotherapy has emerged …

Subclinical doses of Paclitaxel (PTX) given 1day prior to a HER-2/neu (neu)-targeted,
granulocyte–macrophage colony stimulating factor (GM-CSF)-secreting whole-cell vaccine …

Abstract Treatment of metastatic cancer mainly relies on chemotherapy. Chemotherapeutic
agents kill tumor cells by direct cytotoxicity, thus leading to tumor regression. However …

Purpose Tumor cell killing by anticancer drugs may be supported by their immuno-and
pharmacologic effects. Chemotherapy is in fact able to (A) upregulate tumor-associated …

Background: Pancreatic cancer has a poor prognosis. The clinical efficacy of
immunotherapy using both dendritic cells pulsed with MUC1 peptide (MUC1-DC) and …

Simple Summary Immunotherapy hinges on stimulating patients' immune system to fight
cancer. This treatment has led to improved survival in patients with malignancies such as …

Vascular endothelial growth factor receptor 2 (VEGFR2) is an essential factor in tumor
angiogenesis and in the growth of pancreatic cancer. Immunotherapy using epitope peptide …

Colorectal cancer (CRC), a common malignant disease, has the second highest mortality
rate among all cancer types. Due to the diversity and heterogeneity of CRC, few effective …

Tumor-infiltrating T cell rescue by programmed cell death receptor-1 (PD-1)/PD-1 ligand-1
(PD-L1) immune checkpoint blockade is a recommended treatment for malignant diseases …