Purines and their derivatives, most notably adenosine and ATP, are the key molecules
controlling intracellular energy homoeostasis and nucleotide synthesis. Besides, these …

The known seven mammalian receptor subunits (P2X1–7) form cationic channels gated by
ATP. Three subunits compose a receptor channel. Each subunit is a polypeptide consisting …

P2X receptors are trimeric ATP-activated ion channels permeable to Na+, K+ and Ca2+. The
seven P2X receptor subtypes are implicated in physiological processes that include …

Mammalian ATP-gated nonselective cation channels (P2XRs) can be composed of seven
possible subunits, denoted P2X1 to P2X7. Each subunit contains a large ectodomain, two …

P2X receptors are cation-selective ion channels gated by extracellular ATP, and are
implicated in diverse physiological processes, from synaptic transmission to inflammation to …

Acid-sensing ion channels are proton-activated, sodium-selective channels composed of
three subunits, and are members of the superfamily of epithelial sodium channels …

Abstract Ca2+-release-activated Ca2+ (CRAC) channels underlie sustained Ca2+ signalling
in lymphocytes and numerous other cells after Ca2+ liberation from the endoplasmic …

Abstract ATP-gated P2X receptors are trimeric ion channels that assemble as homo-or
heteromers from seven cloned subunits. Transcripts and/or proteins of P2X subunits have …

P2X receptors are ATP-gated cation channels with important roles in diverse
pathophysiological processes. Substantial progress has been made in the last few years …

Changes in intracellular Ca2+ are central to the function of smooth muscle, which lines the
walls of all hollow organs. These changes take a variety of forms, from sustained, cell-wide …