E-cadherin is a transmembrane glycoprotein which connects epithelial cells together at
adherens junctions. In normal cells, E-cadherin exerts its tumour suppressing role mainly by …

Cancer associated fibroblasts (CAFs) and tumor associated macrophages (TAMs) are
among the most important and abundant players of the tumor microenvironment. CAFs as …

Diagnosis of pancreatic ductal adenocarcinoma (PDAC) is associated with a dismal
prognosis despite current best therapies; therefore new treatment strategies are urgently …

Cancer is a key health issue across the world, causing substantial patient morbidity and
mortality. Patient prognosis is tightly linked with metastatic dissemination of the disease to …

Metastasis is the leading reason for the resultant mortality of patients with cancer. The past
few decades have witnessed remarkable progress in understanding the molecular and …

The origins of the mesenchymal cells participating in tissue repair and pathological
processes, notably tissue fibrosis, tumor invasiveness, and metastasis, are poorly …

Without epithelial–mesenchymal transitions, in which polarized epithelial cells are converted
into motile cells, multicellular organisms would be incapable of getting past the blastula …

Background Metastasis is the main cause of mortality in cancer patients. Two major routes of
cancer cell spread are currently being recognized: dissemination via blood vessels …

In addition to their adhesive functions, cell-adhesion molecules modulate signal-
transduction pathways by interacting with molecules such as receptor tyrosine kinases …

Tumor metastasis is driven not only by the accumulation of intrinsic alterations in malignant
cells, but also by the interactions of cancer cells with various stromal cell components of the …