Structure, function, and allosteric modulation of NMDA receptors
NMDA-type glutamate receptors are ligand-gated ion channels that mediate a Ca2+-
permeable component of excitatory neurotransmission in the central nervous system (CNS) …
permeable component of excitatory neurotransmission in the central nervous system (CNS) …
Crystal structure of a heterotetrameric NMDA receptor ion channel
E Karakas, H Furukawa - Science, 2014 - science.org
N-Methyl-d-aspartate (NMDA) receptors belong to the family of ionotropic glutamate
receptors, which mediate most excitatory synaptic transmission in mammalian brains …
receptors, which mediate most excitatory synaptic transmission in mammalian brains …
Molecular mechanism of ligand gating and opening of NMDA receptor
Glutamate transmission and activation of ionotropic glutamate receptors are the fundamental
means by which neurons control their excitability and neuroplasticity. The N-methyl-d …
means by which neurons control their excitability and neuroplasticity. The N-methyl-d …
Mechanism of NMDA receptor inhibition and activation
N-methyl-D-aspartate receptors (NMDARs) are glutamate-gated, calcium-permeable ion
channels that mediate synaptic transmission and underpin learning and memory. NMDAR …
channels that mediate synaptic transmission and underpin learning and memory. NMDAR …
Activation of NMDA receptors and the mechanism of inhibition by ifenprodil
The physiology of N-methyl-d-aspartate (NMDA) receptors is fundamental to brain
development and function. NMDA receptors are ionotropic glutamate receptors that function …
development and function. NMDA receptors are ionotropic glutamate receptors that function …
NMDA receptors in the central nervous system
NMDA-type glutamate receptors are ligand-gated ion channels that mediate a major
component of excitatory neurotransmission in the central nervous system (CNS). They are …
component of excitatory neurotransmission in the central nervous system (CNS). They are …
Structural insights into binding of therapeutic channel blockers in NMDA receptors
Excitatory signaling mediated by N-methyl-d-aspartate receptor (NMDAR) is critical for brain
development and function, as well as for neurological diseases and disorders. Channel …
development and function, as well as for neurological diseases and disorders. Channel …
Mechanistic insight into NMDA receptor dysregulation by rare variants in the GluN2A and GluN2B agonist binding domains
SA Swanger, W Chen, G Wells, PB Burger… - The American Journal of …, 2016 - cell.com
Epilepsy and intellectual disability are associated with rare variants in the GluN2A and
GluN2B (encoded by GRIN2A and GRIN2B) subunits of the N-methyl-D-aspartate receptor …
GluN2B (encoded by GRIN2A and GRIN2B) subunits of the N-methyl-D-aspartate receptor …
Structural basis of functional transitions in mammalian NMDA receptors
TH Chou, N Tajima, A Romero-Hernandez… - Cell, 2020 - cell.com
Excitatory neurotransmission meditated by glutamate receptors including N-methyl-D-
aspartate receptors (NMDARs) is pivotal to brain development and function. NMDARs are …
aspartate receptors (NMDARs) is pivotal to brain development and function. NMDARs are …
Gating mechanism and a modulatory niche of human GluN1-GluN2A NMDA receptors
H Wang, S Lv, D Stroebel, J Zhang, Y Pan, X Huang… - Neuron, 2021 - cell.com
Summary N-methyl-D-aspartate (NMDA) receptors are glutamate-gated calcium-permeable
ion channels that are widely implicated in synaptic transmission and plasticity. Here, we …
ion channels that are widely implicated in synaptic transmission and plasticity. Here, we …